The naïve pluripotent state has been shown in mice to lead to broad and more robust
developmental potential relative to primed mouse epiblast cells. The human naïve ES cell state …

Each unit of the D4Z4 macrosatellite repeat contains a retrotransposed gene encoding the
DUX4 double-homeobox transcription factor. Facioscapulohumeral dystrophy (FSHD) is …

We used massively parallel pyrosequencing to discover and characterize microRNAs (miRNAs)
expressed in human embryonic stem cells (hESC). Sequencing of small RNA cDNA …

Despite progress in developing defined conditions for human embryonic stem cell (hESC)
cultures, little is known about the cell-surface receptors that are activated under conditions …

The diverse progenitors that give rise to the human neocortex have been difficult to
characterize because progenitors, particularly radial glia (RG), are rare and are defined by a …

Understanding how a subset of expressed genes dictates cellular phenotype is a considerable
challenge owing to the large numbers of molecules involved, their combinatorics and the …

We present a CRISPR/Cas9 genome-editing strategy to systematically tag endogenous proteins
with fluorescent tags in human induced pluripotent stem cells (hiPSC). To date, we have …

Studies of embryonic stem cells (ESCs) reveal that these cell lines can be derived from differing
stages of embryonic development. We analyzed common changes in the expression of …

Recent evidence indicates that mouse and human embryonic stem cells (ESCs) are fixed at
different developmental stages, with the former positioned earlier. We show that a narrow …

During human brain development, multiple signaling pathways generate diverse cell types
with varied regional identities. Here, we integrate single-cell RNA sequencing and clonal …