User profiles for Angelo Demuro
Angelo DemuroUniversity Of California Irvine Verified email at uci.edu Cited by 4344 |
[HTML][HTML] Calcium Dysregulation and Membrane Disruption as a Ubiquitous Neurotoxic Mechanism of Soluble Amyloid Oligomers*♦
… Here, Angelo Demuro and colleagues provide more evidence to implicate these soluble
intermediates and to explain just how the oligomers exert their effects on calcium levels. …
intermediates and to explain just how the oligomers exert their effects on calcium levels. …
The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers
Ca 2+ -release-activated Ca 2+ (CRAC) channels underlie sustained Ca 2+ signalling in
lymphocytes and numerous other cells after Ca 2+ liberation from the endoplasmic reticulum (…
lymphocytes and numerous other cells after Ca 2+ liberation from the endoplasmic reticulum (…
[HTML][HTML] Calcium signaling and amyloid toxicity in Alzheimer disease
Intracellular Ca 2+ signaling is fundamental to neuronal physiology and viability. Because
of its ubiquitous roles, disruptions in Ca 2+ homeostasis are implicated in diverse disease …
of its ubiquitous roles, disruptions in Ca 2+ homeostasis are implicated in diverse disease …
SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production
In addition to disrupting the regulated intramembraneous proteolysis of key substrates,
mutations in the presenilins also alter calcium homeostasis, but the mechanism linking …
mutations in the presenilins also alter calcium homeostasis, but the mechanism linking …
Single-channel Ca2+ imaging implicates Aβ1–42 amyloid pores in Alzheimer's disease pathology
Oligomeric forms of Aβ peptides are implicated in Alzheimer’s disease (AD) and disrupt
membrane integrity, leading to cytosolic calcium (Ca 2+ ) elevation. Proposed mechanisms by …
membrane integrity, leading to cytosolic calcium (Ca 2+ ) elevation. Proposed mechanisms by …
[PDF][PDF] CALHM3 is essential for rapid ion channel-mediated purinergic neurotransmission of GPCR-mediated tastes
Binding of sweet, umami, and bitter tastants to G protein-coupled receptors (GPCRs) in apical
membranes of type II taste bud cells (TBCs) triggers action potentials that activate a voltage…
membranes of type II taste bud cells (TBCs) triggers action potentials that activate a voltage…
Cytotoxicity of intracellular aβ42 amyloid oligomers involves Ca2+ release from the endoplasmic reticulum by stimulated production of inositol trisphosphate
Oligomeric forms of β-amyloid (Aβ) peptides associated with Alzheimer's disease (AD) disrupt
cellular Ca 2+ regulation by liberating Ca 2+ into the cytosol from both extracellular and …
cellular Ca 2+ regulation by liberating Ca 2+ into the cytosol from both extracellular and …
[HTML][HTML] Structural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexins
CALHM1 (calcium homeostasis modulator 1) forms a plasma membrane ion channel that
mediates neuronal excitability in response to changes in extracellular Ca 2+ concentration. Six …
mediates neuronal excitability in response to changes in extracellular Ca 2+ concentration. Six …
Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states
We applied single-molecule photobleaching to investigate the stoichiometry of human Orai1
and Orai3 channels tagged with eGFP and expressed in mammalian cells. Orai1 was …
and Orai3 channels tagged with eGFP and expressed in mammalian cells. Orai1 was …
“Optical Patch-clamping” Single-channel Recording by Imaging Ca2+ Flux through Individual Muscle Acetylcholine Receptor Channels
We describe an optical technique using total internal reflection fluorescence (TIRF) microscopy
to obtain simultaneous and independent recordings from numerous ion channels via …
to obtain simultaneous and independent recordings from numerous ion channels via …