About 20% of all human cancers are caused by chronic infection or chronic inflammatory
states. Recently, a new hypothesis has been proposed for prostate carcinogenesis. It proposes …

This review focuses on new findings and controversial issues in the pathology and molecular
biology of adenocarcinoma of the prostate. Since management of high-grade prostatic …

… Gurel, MS Lucia, EA Platz and AM De Marzo, manuscript in preparation). These preliminary
studies revealed that chronic inflammation in benign tissue of a needle biopsy was …

Neovascularization and increased glycolysis, two universal characteristics of solid tumors,
represent adaptations to a hypoxic microenvironment that are correlated with tumor invasion, …

Background The androgen-receptor isoform encoded by splice variant 7 lacks the ligand-binding
domain, which is the target of enzalutamide and abiraterone, but remains constitutively …

Altered glucose metabolism in cancer cells is termed the Warburg effect, which describes the
propensity of most cancer cells to take up glucose avidly and convert it primarily to lactate, …

Proliferation in the setting of longstanding chronic inflammation appears to predispose to
carcinoma in the liver, large bowel, urinary bladder, and gastric mucosa. Focal prostatic atrophy…

Identification of genes that are dysregulated in association with prostate carcinogenesis can
provide disease markers and clues relevant to disease etiology. Of particular interest as …

DNA double-strand breaks (DSBs) can lead to the development of genomic rearrangements,
which are hallmarks of cancer. Fusions between TMPRSS2, encoding the transmembrane …

Aberrant DNA methylation patterns may be the earliest somatic genome changes in
prostate cancer. Using real-time methylation-specific PCR, we assessed the extent of …