Intestinal organoids capture essential features of the intestinal epithelium such as crypt
folding, cellular compartmentalization and collective movements. Each of these processes and …

Cerebellar granular neuronal precursors (CGNPs) proliferate in response to the mitogenic
activity of Sonic hedgehog (Shh), and this proliferation is negatively regulated by activation of …

Protein kinase A (PKA) accumulates at the base of the cilium where it negatively regulates
the Hedgehog (Hh) pathway. Although PKA activity is essentially controlled by the cAMP …

Background & Aims Liver fibrosis, an important health concern associated to chronic liver
injury that provides a permissive environment for cancer development, is characterized by …

10.7554/eLife.37267.001 Class II HLH proteins heterodimerize with class I HLH/E proteins
to regulate transcription. Here, we show that E proteins sharpen neurogenesis by adjusting …

Proliferation of cerebellar granular neuronal precursors (CGNPs) is mediated by Sonic
Hedgehog (Shh), which activates the Patched and Smoothened (Smo) receptor complex. …

β-Catenin mediates the canonical Wnt pathway by stimulating Tcf-dependent transcription
and also associates to N-cadherin at the apical complex (AC) of neuroblasts. Here, we show …

The neural tube forms when neural stem cells arrange into a pseudostratified, single-cell–layered
epithelium, with a marked apico-basal polarity, and in which adherens junctions (AJs) …

Vinculin is an actin-binding protein (ABP) that strengthens the connection between the actin
cytoskeleton and adhesion complexes. It binds to β-catenin/N-cadherin complexes in apical …

Here, we show that, in the developing spinal cord, after the early Wnt-mediated Tcf transcription
activation that confers dorsal identity to neural stem cells, neurogenesis redirects β-…