Variants of uncertain significance fundamentally limit the clinical utility of genetic information.
The challenge they pose is epitomized by BRCA1, a tumour suppressor gene in which …

Variants of uncertain significance (VUS) fundamentally limit the utility of genetic 1 information
in a clinical setting. The challenge of VUS is epitomized by BRCA1, a tumor 2 suppressor …

… concentrations in ECV after ANH. Based on this balance, a comparison was made between
the respective predicted electrolyte concentrations after ANH and our measured values. …

… Distributions of observed versus expected p values for candidate enhancer-targeting … to
assign a threshold for calling pairs (p value on whether 3/16 disagrees with 10% FDR = 0.21). …

Asthma is a heterogeneous disease characterized by airway inflammation and hyperreactivity.
IL-17 receptor A (IL-17RA) is a shared receptor subunit required for activity of IL-17 family …

There is an unmet need in severe asthma where approximately 40% of patients exhibit poor
β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations. …

Current methods to delete genomic sequences are based on clustered regularly interspaced
short palindromic repeats (CRISPR)–Cas9 and pairs of single-guide RNAs (sgRNAs), but …

Measurements of gene expression and signal transduction activity are conventionally
performed with methods that require either the destruction or live imaging of a biological sample …

Measurements of gene expression and signal transduction activity are conventionally
performed with methods that require either the destruction or live imaging of a biological sample …

… intergroup differences before and after ANH. AP value of 0.05 for intergroup differences
before ANH and a value of 0.002 for intergroup differences after ANH and intragroup differences (…