Diabetes mellitus is a multifactorial disease affecting increasing numbers of patients
worldwide. Progression to insulin-dependent diabetes mellitus is characterized by the loss or …

Deciphering mechanisms of endocrine cell induction, specification and lineage allocation in
vivo will provide valuable insights into how the islets of Langerhans are generated. Currently…

Dedifferentiation of insulin-secreting β cells in the islets of Langerhans has been proposed
to be a major mechanism of β-cell dysfunction. Whether dedifferentiated β cells can be …

Background Diabetes mellitus is characterized by loss or dysfunction of insulin-producing β-cells
in the pancreas, resulting in failure of blood glucose regulation and devastating …

Single cell RNA-seq has revolutionized transcriptomics by providing cell type resolution for
differential gene expression and expression quantitative trait loci (eQTL) analyses. However, …

Objective Hundreds of missense mutations in the coding region of PDX1 exist; however, if
these mutations predispose to diabetes mellitus is unknown. Methods In this study, we …

Although multiple pancreatic islet single-cell RNA-sequencing (scRNA-seq) datasets have
been generated, a consensus on pancreatic cell states in development, homeostasis and …

It is generally accepted that epiblast cells ingress into the primitive streak by epithelial-to-mesenchymal
transition (EMT) to give rise to the mesoderm; however, it is less clear how the …

Excess nutrient uptake and altered hormone secretion in the gut contribute to a systemic
energy imbalance, which causes obesity and an increased risk of type 2 diabetes and …

Objective Pancreatic islets of Langerhans secrete hormones to regulate systemic glucose
levels. Emerging evidence suggests that islet cells are functionally heterogeneous to allow a …