User profiles for Anil Korkut

Anil Korkut

MD Anderson Cancer Center
Verified email at mdanderson.org
Cited by 32180

[PDF][PDF] A comprehensive pan-cancer molecular study of gynecologic and breast cancers

AC Berger, A Korkut, RS Kanchi, AM Hegde, W Lenoir… - Cancer cell, 2018 - cell.com
We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of
four gynecological types plus breast. Our aims were to identify shared and unique molecular …

[PDF][PDF] The immune landscape of cancer

…, BM Broom, AM Hegde, Z Ju, RS Kanchi, A Korkut… - Immunity, 2018 - cell.com
We performed an extensive immunogenomic analysis of more than 10,000 tumors comprising
33 diverse cancer types by utilizing data compiled by TCGA. Across cancer types, we …

[PDF][PDF] Genomic classification of cutaneous melanoma

…, FR Khuri, J Kim, JM Kirkwood, J Klode, A Korkut… - Cell, 2015 - cell.com
We describe the landscape of genomic alterations in cutaneous melanomas through DNA,
RNA, and protein-based analysis of 333 primary and/or metastatic melanomas from 331 …

[PDF][PDF] An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics

…, BM Broom, AM Hegde, Z Ju, RS Kanchi, A Korkut… - Cell, 2018 - cell.com
For a decade, The Cancer Genome Atlas (TCGA) program collected clinicopathologic
annotation data along with multi-platform molecular profiles of more than 11,000 human tumors …

[PDF][PDF] Oncogenic signaling pathways in the cancer genome atlas

…, BM Broom, AM Hegde, Z Ju, RS Kanchi, A Korkut… - Cell, 2018 - cell.com
Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and
cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-…

[PDF][PDF] Comprehensive characterization of cancer driver genes and mutations

…, BM Broom, AM Hegde, Z Ju, RS Kanchi, A Korkut… - Cell, 2018 - cell.com
Identifying molecular cancer drivers is critical for precision oncology. Multiple advanced
algorithms to identify drivers now exist, but systematic attempts to combine and optimize them on …

[PDF][PDF] Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer

…, BM Broom, AM Hegde, Z Ju, RS Kanchi, A Korkut… - Cell, 2018 - cell.com
We conducted comprehensive integrative molecular analyses of the complete set of tumors
in The Cancer Genome Atlas (TCGA), consisting of approximately 10,000 specimens and …

[PDF][PDF] Machine learning identifies stemness features associated with oncogenic dedifferentiation

…, BM Broom, AM Hegde, Z Ju, RS Kanchi, A Korkut… - Cell, 2018 - cell.com
Cancer progression involves the gradual loss of a differentiated phenotype and acquisition
of progenitor and stem-cell-like features. Here, we provide novel stemness indices for …

[PDF][PDF] Integrated genomic characterization of pancreatic ductal adenocarcinoma

…, D Tan, U Veluvolu, JS Parker, MD Wilkerson, A Korkut… - Cancer cell, 2017 - cell.com
We performed integrated genomic, transcriptomic, and proteomic profiling of 150 pancreatic
ductal adenocarcinoma (PDAC) specimens, including samples with characteristic low …

[PDF][PDF] Genomic and molecular landscape of DNA damage repair deficiency across the cancer genome atlas

…, BM Broom, AM Hegde, Z Ju, RS Kanchi, A Korkut… - Cell reports, 2018 - cell.com
DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic
response. We systematically analyzed somatic alterations to provide a comprehensive view of …