Monocyte chemoattractant protein-1 (MCP-1) has been implicated in many inflammatory
and autoimmune diseases. The G-protein-coupled receptor CCR-2B is probably the most …

Inflammatory processes have been implicated in the pathogenesis of brain damage after
stroke. In rodent stroke models, focal ischemia induces several proinflammatory chemokines, …

Nogo-A is a myelin-associated neurite outgrowth inhibitory protein limiting recovery and
plasticity after central nervous system injury. In this study, a purified monoclonal anti—Nogo-A …

Interleukin‐1β (IL‐1β) may play a central role in the inflammatory response following traumatic
brain injury (TBI). We subjected 91 mice to controlled cortical impact (CCI) brain injury or …

Increasing evidence suggests that interleukin‐1β (IL‐1β) is a key mediator of the
inflammatory response following traumatic brain injury (TBI). Recently, we showed that …

Stroke is a prevalent and devastating disorder, and no treatment is currently available to
restore lost neuronal function after stroke. One unique therapy that improves recovery after …

Background BAF312 (Siponimod) is a dual agonist at the sphingosine-1 phosphate receptors,
S1PR1 and S1PR5. This drug is currently undergoing clinical trials for the treatment of …

Triggering receptor expressed in myeloid cells (TREM2) is a member of the immunoglobulin
superfamily and is expressed in macrophages, dendritic cells, microglia, and osteoclasts. …

The family of interleukin 17 receptors (IL17Rs), subtypes IL17RA‐IL17RE, is targeted by the
group of pro‐inflammatory IL17 cytokines (IL17A‐F) and moreover the newly developed anti…

Blocking the function of the myelin protein Nogo-A or its signaling pathway is a promising
method to overcome an important neurite growth inhibitory factor of the adult central nervous …