Metastatic progression is the main cause of death in cancer patients, whereas the underlying
genomic mechanisms driving metastasis remain largely unknown. Here, we assembled …

The incidence of rectal cancer is increasing in patients younger than 50 years. Locally advanced
rectal cancer is still treated with neoadjuvant radiation, chemotherapy and surgery, but …

The genetic, biologic, and clinical heterogeneity of sarcomas poses a challenge for the
identification of therapeutic targets, clinical research, and advancing patient care. Because there …

CRISPR homing gene drives can convert heterozygous cells with one copy of the drive
allele into homozygotes, thereby enabling super-Mendelian inheritance. Such a mechanism …

Background Patterns of metastasis in cancer are increasingly relevant to prognostication
and treatment planning but have historically been documented by means of autopsy series. …

Gene drives could allow for control of vector-borne diseases by directly suppressing vector
populations or spreading genetic payloads designed to reduce pathogen transmission. …

Importance Brain metastasis (BrM) in gastroesophageal adenocarcinoma (GEA) is a rare
and poorly understood phenomenon associated with poor prognosis. Objectives To examine …

Simple Summary Radiation therapy is commonly used in the treatment of prostate cancer,
but it is a carcinogen itself. Long-term survivors of prostate cancer who were treated with …

Estimating fitness differences between allelic variants is a central goal of experimental
evolution. Current methods for inferring such differences from allele frequency time series …

During the past decade, next‐generation sequencing (NGS) technologies have become
widely adopted in cancer research and clinical care. Common applications within the clinical …