To enable new blood vessel growth, endothelial cells (ECs) express neuropilin 1 (NRP1),
and NRP1 associates with the receptor tyrosine kinase VEGFR2 after binding the vascular …

Keratin 16 (K16) is a cytoskeletal scaffolding protein highly expressed at pressure-bearing
sites of the mammalian footpad. It can be induced in hyperproliferative states such as wound …

Epidermal keratinocytes migrate through the epidermis up to the granular layer where, on
terminal differentiation, they progressively lose organelles and convert into anucleate cells or …

iASPP, an inhibitory member of the ASPP (apoptosis stimulating protein of p53) family, is an
evolutionarily conserved inhibitor of p53 which is frequently upregulated in human cancers. …

The transmembrane protein neuropilin-1 (NRP1) promotes vascular endothelial growth
factor (VEGF) and extracellular matrix signaling in endothelial cells (ECs). Although it is …

The protein iASPP (encoded by PPP1R13L) is an evolutionarily conserved p53 inhibitor, the
expression of which is often upregulated in human cancers. We have recently shown that …

The epidermis, the outer layer of the skin composed of keratinocytes, develops following the
action of the transcription factor p63. The mouse Trp63 gene contains two promoters, driving …

Linear and disturbed flow differentially regulate gene expression, with disturbed flow
priming endothelial cells (ECs) for a proinflammatory, atheroprone expression profile and …

The role of apoptosis in melanoma pathogenesis and chemoresistance is poorly characterized.
Mutations in TP53 occur infrequently, yet the TP53 apoptotic pathway is often abrogated. …

3-Phosphoinositide-dependent protein kinase-1 (PDK1) and phospholipase C (PLC)γ1 are
two key enzymes in signal transduction that control several intracellular processes. Despite …