Many common variants have been associated with hematological traits, but identification of
causal genes and pathways has proven challenging. We performed a genome-wide …

MethylCap-seq is a robust procedure for genome-wide profiling of DNA methylation. The
approach consists of the capture of methylated DNA using the MBD domain of MeCP2, and …

Epigenetic regulatory mechanisms and their enzymes are promising targets for malaria
therapeutic intervention; however, the epigenetic component of gene expression in P. falciparum …

Malaria kills >1 million people each year, in particular in sub-Saharan Africa. Although
asexual forms are directly responsible for disease and death, sexual stages account for the …

The gene encoding the gametocyte/gamete-specific membrane protein Pfs 48 45 of Plasmodium
falciparum has been cloned. The Pfs48/45 gene is a non-interrupted, single copy gene …

Pfs48/45, a member of a Plasmodium-specific protein family, displays conformation-dependent
epitopes and is an important target for malaria transmission-blocking (TB) immunity. To …

Aberrant DNA methylation often occurs in colorectal cancer (CRC). In our study we applied a
genome-wide DNA methylation analysis approach, MethylCap-seq, to map the differentially …

Transmission of malaria depends on the successful development of the sexual stages of the
parasite within the midgut of the mosquito vector. The differentiation process leading to the …

Embryonic Stem Cells (ESCs) and Epiblast Stem Cells (EpiSCs) are the in vitro
representatives of naïve and primed pluripotency, respectively. It is currently unclear how their …

Sin3A or Sin3B are components of a corepressor complex that mediates repression by
transcription factors such as the helix-loop-helix proteins Mad and Mxi. Members of the Mad/Mxi …