Rationale: Cerebrovascular function is critical for brain health, and endogenous vascular
protective pathways may provide therapeutic targets for neurological disorders. S1P (…

In common with other chronic pain conditions, there is an unmet clinical need in the treatment
of inherited erythromelalgia (IEM). The SCN9A gene encoding the sodium channel Nav1.7 …

The interpretation of genome sequences requires reliable and standardized methods to assess
protein function at high throughput. Here we describe a fast and reliable pipeline to study …

Pluripotent embryonic stem cells (ESCs) maintain self-renewal while ensuring a rapid response
to differentiation cues. The identification of genes maintaining ESC identity is important …

Cell signalling governs cellular behaviour and is therefore subject to tight spatiotemporal
regulation. Signalling output is modulated by specialized cell membranes and vesicles which …

For self-renewal, embryonic stem cells (ESCs) require the expression of specific transcription
factors accompanied by a particular chromosome organization to maintain a balance …

Bacterial products can act on neurons to alter signaling and function. In the present study, we
found that dorsal root ganglion (DRG) sensory neurons are enriched for ANTXR2, the high-…

Whereas methods to comprehensively study cellular roles of protein-coding genes are
available, techniques to systematically investigate long noncoding RNAs (lncRNAs), which have …

Despite the medical importance of G protein-coupled receptors (GPCRs), in vivo cellular
heterogeneity of GPCR signaling and downstream transcriptional responses are not understood…

The Notch signaling pathway is essential for normal development due to its role in control of
cell differentiation, proliferation and survival. It is also critically involved in tumorigenesis …