User profiles for Anja S. Knaupp
 | Anja KnauppMonash University Verified email at monash.edu Cited by 1365 |
A predictive computational framework for direct reprogramming between human cell types
Transdifferentiation, the process of converting from one cell type to another without going
through a pluripotent state, has great promise for regenerative medicine. The identification of …
through a pluripotent state, has great promise for regenerative medicine. The identification of …
Reprogramming roadmap reveals route to human induced trophoblast stem cells
The reprogramming of human somatic cells to primed or naive induced pluripotent stem cells
recapitulates the stages of early embryonic development 1 , 2 , 3 , 4 , 5 – 6 . The molecular …
recapitulates the stages of early embryonic development 1 , 2 , 3 , 4 , 5 – 6 . The molecular …
Comprehensive characterization of distinct states of human naive pluripotency generated by reprogramming
Recent reports on the characteristics of naive human pluripotent stem cells (hPSCs) obtained
using independent methods differ. Naive hPSCs have been mainly derived by conversion …
using independent methods differ. Naive hPSCs have been mainly derived by conversion …
[PDF][PDF] Transient and permanent reconfiguration of chromatin and transcription factor occupancy drive reprogramming
Somatic cell reprogramming into induced pluripotent stem cells (iPSCs) induces changes in
genome architecture reflective of the embryonic stem cell (ESC) state. However, only a small …
genome architecture reflective of the embryonic stem cell (ESC) state. However, only a small …
SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program
10.7554/eLife.37419.001 The establishment and maintenance of pluripotency depend on
precise coordination of gene expression. We establish serine-arginine-rich splicing factor 3 (…
precise coordination of gene expression. We establish serine-arginine-rich splicing factor 3 (…
[PDF][PDF] Cell type of origin dictates the route to pluripotency
Our current understanding of induced pluripotent stem cell (iPSC) generation has almost
entirely been shaped by studies performed on reprogramming fibroblasts. However, whether …
entirely been shaped by studies performed on reprogramming fibroblasts. However, whether …
[PDF][PDF] Nucleocytoplasmic coagulation: an injury-induced aggregation event that disulfide crosslinks proteins and facilitates their removal by plasmin
Cellular injury causes a myriad of processes that affect proteostasis. We describe nucleocytoplasmic
coagulation (NCC), an intracellular disulfide-dependent protein crosslinking event …
coagulation (NCC), an intracellular disulfide-dependent protein crosslinking event …
[HTML][HTML] Oxidation of an exposed methionine instigates the aggregation of glyceraldehyde-3-phosphate dehydrogenase
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a ubiquitous and abundant protein
that participates in cellular energy production. GAPDH normally exists in a soluble form; …
that participates in cellular energy production. GAPDH normally exists in a soluble form; …
[HTML][HTML] Retrotransposon instability dominates the acquired mutation landscape of mouse induced pluripotent stem cells
…, L Walker, AL Carleton, C James, AS Knaupp… - Nature …, 2022 - nature.com
Induced pluripotent stem cells (iPSCs) can in principle differentiate into any cell of the body,
and have revolutionized biomedical research and regenerative medicine. Unlike their …
and have revolutionized biomedical research and regenerative medicine. Unlike their …
[PDF][PDF] A versatile strategy for isolating a highly enriched population of intestinal stem cells
The isolation of pure populations of mouse intestinal stem cells (ISCs) is essential to facilitate
functional studies of tissue homeostasis, tissue regeneration, and intestinal diseases. …
functional studies of tissue homeostasis, tissue regeneration, and intestinal diseases. …