The signal transducer and activator of transcription 3 (STAT3), a nuclear transcription factor,
is also present in mitochondria and regulates cellular respiration in a transcriptional-…

Cardiolipin (CL) is a mitochondrial phospholipid with a very specific and functionally
important fatty acid composition, generated by tafazzin. However, in vitro tafazzin catalyzes a …

Respiratory complex I is a proton-pumping oxidoreductase key to bioenergetic metabolism.
Biochemical studies have found a divide in the behavior of complex I in metazoans that …

Several subunits in the matrix domain of mitochondrial complex I (CI) have been posited to
be redox sensors for CI, but how elevated levels of reactive oxygen species (ROS) impinge …

NADH:ubiquinone oxidoreductase, more commonly referred to as mitochondrial complex I (CI),
is the largest discrete enzyme of the oxidative phosphorylation system (OXPHOS). It is …

Acute Lung Injury (ALI) due to inhaled pathogens causes high mortality. Underlying mechanisms
are inadequately understood. Here, by optical imaging of live mouse lungs we show …

An ability to comprehensively track the assembly intermediates (AIs) of complex I (CI)
biogenesis in Drosophila will enable the characterization of the precise mechanism (s) by which …

Despite the growing evidence of the role of oxidative stress in disease, its molecular mechanism
of action remains poorly understood. The yeast Saccharomyces cerevisiae provides a …

Distinct sub-assemblies (modules) of mitochondrial complex I (CI) are assembled with the
assistance of CI Assembly Factors (CIAFs) through mechanisms that are incompletely defined. …

Several phospholipid (PL) molecules are intertwined with some mitochondrial complex I (CI)
subunits in the membrane domain of CI, but their function is unclear. We report that when …