Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants
MT Hemann, A Bric, J Teruya-Feldstein, A Herbst… - Nature, 2005 - nature.com
The c-Myc oncoprotein promotes proliferation and apoptosis, such that mutations that disable
apoptotic programmes often cooperate with MYC during tumorigenesis. Here we report …
apoptotic programmes often cooperate with MYC during tumorigenesis. Here we report …
[PDF][PDF] Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model
Short hairpin RNAs (shRNAs) capable of stably suppressing gene function by RNA interference
(RNAi) can mimic tumor-suppressor-gene loss in mice. By selecting for shRNAs capable …
(RNAi) can mimic tumor-suppressor-gene loss in mice. By selecting for shRNAs capable …
Discovery of orally active inhibitors of brahma homolog (BRM)/SMARCA2 ATPase activity for the treatment of brahma related gene 1 (BRG1)/SMARCA4-mutant …
…, G Chenail, HEC Bhang, A Bric… - Journal of medicinal …, 2018 - ACS Publications
SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily A
member 2 (SMARCA2), also known as Brahma homologue (BRM), is a Snf2-family DNA-…
member 2 (SMARCA2), also known as Brahma homologue (BRM), is a Snf2-family DNA-…
DR5 knockout mice are compromised in radiation-induced apoptosis
…, JJ Gruber, P Fei, D Rudolph, A Bric… - … and cellular biology, 2005 - Taylor & Francis
DR5 (also called TRAIL receptor 2 and KILLER) is an apoptosis-inducing membrane receptor
for tumor necrosis factor-related apoptosis-inducing ligand (also called TRAIL and Apo2 …
for tumor necrosis factor-related apoptosis-inducing ligand (also called TRAIL and Apo2 …
The discovery of SWI/SNF chromatin remodeling activity as a novel and targetable dependency in uveal melanoma
…, KX Xiang, G Bushold, Y Feng, MD Shirley, A Bric… - Molecular cancer …, 2020 - AACR
Uveal melanoma is a rare and aggressive cancer that originates in the eye. Currently, there
are no approved targeted therapies and very few effective treatments for this cancer. …
are no approved targeted therapies and very few effective treatments for this cancer. …
Discovery of Darovasertib (NVP-LXS196), a Pan-PKC Inhibitor for the Treatment of Metastatic Uveal Melanoma
…, C Joud, R Barrett, A Vattay, R Guo, A Bric… - Journal of medicinal …, 2024 - ACS Publications
Uveal melanoma (UM) is the most common primary intraocular malignancy in the adult eye.
Despite the aggressive local management of primary UM, the development of metastases is …
Despite the aggressive local management of primary UM, the development of metastases is …
Enforced expression of PPP1R13L increases tumorigenesis and invasion through p53‐dependent and p53‐independent mechanisms
PPP1R13L was initially identified as a protein that binds to the NF‐κB subunit p65/RelA and
inhibits its transcriptional activity. It also binds p53 and inhibits its action. One set of …
inhibits its transcriptional activity. It also binds p53 and inhibits its action. One set of …
In-Depth Characterization and Validation in BRG1-Mutant Lung Cancers Define Novel Catalytic Inhibitors of SWI/SNF Chromatin Remodeling
…, A Li, GN Elliott, J Zhu, A Vattay, T Gilbert, A Bric… - Biorxiv, 2019 - biorxiv.org
Members of the ATP-dependent SWI/SNF chromatin remodeling complexes are among the
most frequently mutated genes in cancer, suggesting their dysregulation plays a critical role. …
most frequently mutated genes in cancer, suggesting their dysregulation plays a critical role. …
[HTML][HTML] Photocross-linking of the RNA polymerase I preinitiation and immediate postinitiation complexes: implications for promoter recruitment
A Bric, CA Radebaugh, MR Paule - Journal of Biological Chemistry, 2004 - ASBMB
The architecture of eukaryotic rRNA transcription complexes was analyzed, revealing facts
significant to the RNA polymerase (pol) I initiation process. Functional initiation and …
significant to the RNA polymerase (pol) I initiation process. Functional initiation and …
[BOOK][B] Analysis of promoter-transcription factor interactions by site-specific photo-cross-linking
A Bric - 2002 - search.proquest.com
Cells depend upon the proper functioning of proteins for cell cycle regulation and controlled
cell growth, factors whose malfunction contributes to many human diseases. Transcription of …
cell growth, factors whose malfunction contributes to many human diseases. Transcription of …