Plasticity of animal genome architecture unmasked by rapid evolution of a pelagic tunicate
…, A Louis, S Butcher, G Tsagkogeorga, A Konrad… - Science, 2010 - science.org
Genomes of animals as different as sponges and humans show conservation of global
architecture. Here we show that multiple genomic features including transposon diversity, …
architecture. Here we show that multiple genomic features including transposon diversity, …
[HTML][HTML] Two modes of evolution shape bacterial strain diversity in the mammalian gut for thousands of generations
How and at what pace bacteria evolve when colonizing healthy hosts remains unclear. Here,
by monitoring evolution for more than six thousand generations in the mouse gut, we show …
by monitoring evolution for more than six thousand generations in the mouse gut, we show …
Growth of keratinocytes on porous films of poly (3‐hydroxybutyrate) and poly (4‐hydroxybutyrate) blended with hyaluronic acid and chitosan
G Peschel, HM Dahse, A Konrad… - … Research Part A: An …, 2008 - Wiley Online Library
The objective of this study was to develop novel absorbable films suitable for use as a tissue‐engineering
scaffold for keratinocytes as a therapy for replacement of damaged skin. Poly(4…
scaffold for keratinocytes as a therapy for replacement of damaged skin. Poly(4…
Mitochondrial Mutation Rate, Spectrum and Heteroplasmy in Caenorhabditis elegans Spontaneous Mutation Accumulation Lines of Differing Population Size
A Konrad, O Thompson, RH Waterston… - Molecular Biology …, 2017 - academic.oup.com
Mitochondrial genomes of metazoans, given their elevated rates of evolution, have served
as pivotal markers for phylogeographic studies and recent phylogenetic events. In order to …
as pivotal markers for phylogeographic studies and recent phylogenetic events. In order to …
Mutational and transcriptional landscape of spontaneous gene duplications and deletions in Caenorhabditis elegans
A Konrad, S Flibotte, J Taylor… - Proceedings of the …, 2018 - National Acad Sciences
Gene duplication and deletion are pivotal processes shaping the structural and functional
repertoire of genomes, with implications for disease, adaptation, and evolution. We employed …
repertoire of genomes, with implications for disease, adaptation, and evolution. We employed …
Toward a general model for the evolutionary dynamics of gene duplicates
A Konrad, AI Teufel, JA Grahnen… - Genome biology and …, 2011 - academic.oup.com
Gene duplication is an important process in the functional divergence of genes and
genomes. Several processes have been described that lead to duplicate gene retention over …
genomes. Several processes have been described that lead to duplicate gene retention over …
Mutational Landscape of Spontaneous Base Substitutions and Small Indels in Experimental Caenorhabditis elegans Populations of Differing Size
Experimental investigations into the rates and fitness effects of spontaneous mutations are
fundamental to our understanding of the evolutionary process. To gain insights into the …
fundamental to our understanding of the evolutionary process. To gain insights into the …
Mutation rate and spectrum in obligately outcrossing Caenorhabditis elegans mutation accumulation lines subjected to RNAi-induced knockdown of the mismatch …
V Katju, A Konrad, TC Deiss, U Bergthorsson - G3, 2022 - academic.oup.com
DNA mismatch repair (MMR), an evolutionarily conserved repair pathway shared by prokaryotic
and eukaryotic species alike, influences molecular evolution by detecting and correcting …
and eukaryotic species alike, influences molecular evolution by detecting and correcting …
Mutation accumulation and horizontal gene transfer in Escherichia coli colonizing the gut of old mice
The ecology and environment of the microbes that inhabit the mammalian intestine undergoes
several changes as the host ages. Here, we ask if the selection pressure experienced by …
several changes as the host ages. Here, we ask if the selection pressure experienced by …
Deoxyribonucleoside kinases in two aquatic bacteria with high specificity for thymidine and deoxyadenosine
T Tinta, LS Christiansen, A Konrad… - FEMS microbiology …, 2012 - academic.oup.com
Deoxyribonucleoside kinases (dNKs) are essential in the mammalian cell but their ‘importance’
in bacteria, especially aquatic ones, is less clear. We studied two aquatic bacteria, Gram-…
in bacteria, especially aquatic ones, is less clear. We studied two aquatic bacteria, Gram-…