Plasticity of animal genome architecture unmasked by rapid evolution of a pelagic tunicate

…, A Louis, S Butcher, G Tsagkogeorga, A Konrad… - Science, 2010 - science.org
Genomes of animals as different as sponges and humans show conservation of global
architecture. Here we show that multiple genomic features including transposon diversity, …

[HTML][HTML] Two modes of evolution shape bacterial strain diversity in the mammalian gut for thousands of generations

N Frazão, A Konrad, M Amicone, E Seixas… - Nature …, 2022 - nature.com
How and at what pace bacteria evolve when colonizing healthy hosts remains unclear. Here,
by monitoring evolution for more than six thousand generations in the mouse gut, we show …

Growth of keratinocytes on porous films of poly (3‐hydroxybutyrate) and poly (4‐hydroxybutyrate) blended with hyaluronic acid and chitosan

G Peschel, HM Dahse, A Konrad… - … Research Part A: An …, 2008 - Wiley Online Library
The objective of this study was to develop novel absorbable films suitable for use as a tissue‐engineering
scaffold for keratinocytes as a therapy for replacement of damaged skin. Poly(4…

Mitochondrial Mutation Rate, Spectrum and Heteroplasmy in Caenorhabditis elegans Spontaneous Mutation Accumulation Lines of Differing Population Size

A Konrad, O Thompson, RH Waterston… - Molecular Biology …, 2017 - academic.oup.com
Mitochondrial genomes of metazoans, given their elevated rates of evolution, have served
as pivotal markers for phylogeographic studies and recent phylogenetic events. In order to …

Mutational and transcriptional landscape of spontaneous gene duplications and deletions in Caenorhabditis elegans

A Konrad, S Flibotte, J Taylor… - Proceedings of the …, 2018 - National Acad Sciences
Gene duplication and deletion are pivotal processes shaping the structural and functional
repertoire of genomes, with implications for disease, adaptation, and evolution. We employed …

Toward a general model for the evolutionary dynamics of gene duplicates

A Konrad, AI Teufel, JA Grahnen… - Genome biology and …, 2011 - academic.oup.com
Gene duplication is an important process in the functional divergence of genes and
genomes. Several processes have been described that lead to duplicate gene retention over …

Mutational Landscape of Spontaneous Base Substitutions and Small Indels in Experimental Caenorhabditis elegans Populations of Differing Size

A Konrad, MJ Brady, U Bergthorsson, V Katju - Genetics, 2019 - academic.oup.com
Experimental investigations into the rates and fitness effects of spontaneous mutations are
fundamental to our understanding of the evolutionary process. To gain insights into the …

Mutation rate and spectrum in obligately outcrossing Caenorhabditis elegans mutation accumulation lines subjected to RNAi-induced knockdown of the mismatch …

V Katju, A Konrad, TC Deiss, U Bergthorsson - G3, 2022 - academic.oup.com
DNA mismatch repair (MMR), an evolutionarily conserved repair pathway shared by prokaryotic
and eukaryotic species alike, influences molecular evolution by detecting and correcting …

Mutation accumulation and horizontal gene transfer in Escherichia coli colonizing the gut of old mice

HC Barreto, N Frazão, A Sousa, A Konrad… - … & Integrative Biology, 2020 - Taylor & Francis
The ecology and environment of the microbes that inhabit the mammalian intestine undergoes
several changes as the host ages. Here, we ask if the selection pressure experienced by …

Deoxyribonucleoside kinases in two aquatic bacteria with high specificity for thymidine and deoxyadenosine

T Tinta, LS Christiansen, A Konrad… - FEMS microbiology …, 2012 - academic.oup.com
Deoxyribonucleoside kinases (dNKs) are essential in the mammalian cell but their ‘importance’
in bacteria, especially aquatic ones, is less clear. We studied two aquatic bacteria, Gram-…