This report describes the behavioral and electrophysiological analysis of regulatable transgenic
mice expressing mutant repeat domains of human Tau (Tau RD ). Mice were generated …

Alzheimer’s disease is characterized by the deposition of amyloid-β as extracellular
plaques and hyperphosphorylated tau as intracellular neurofibrillary tangles. Tau pathology …

Tau has been implicated in the organization, stabilization, and dynamics of microtubules. In
Alzheimer's disease and more than 20 neurologic disorders tau missorting, …

Neurofibrillary lesions of abnormal Tau are hallmarks of Alzheimer disease and frontotemporal
dementias. Our regulatable (Tet-OFF) mouse models of tauopathy express variants of …

We evaluated various forms of hippocampus-dependent learning and memory, and
hippocampal synaptic plasticity in THY-Tau22 transgenic mice, a murine tauopathy model that …

Accumulation of amyloid-β plaques and tau contribute to the pathogenesis of Alzheimer’s
disease (AD), but it is unclear whether targeting tau pathology by antioxidants independently …

Age-related cognitive decline and neurodegenerative diseases are a growing challenge for
society. Accumulation of tau pathology has been proposed to partially contribute to these …

Age is a critical factor in the prevalence of tauopathies, including Alzheimer's disease. To
observe how an aging phenotype interacts with and affects the pathological intracellular …

Frontotemporal lobar degeneration (FTLD) is a neurodegenerative disorder, a major subset
of which is characterized by the accumulation of abnormal forms of the protein tau, leading …

The accumulation of proteins such as Tau is a hallmark of several neurodegenerative
diseases, eg, frontotemporal dementia (FTD). So far, many mouse models of tauopathies have …