Oestrogens exert their physiological effects through two receptor subtypes. Here we report
the three‐dimensional structure of the oestrogen receptor beta isoform (ERβ) ligand‐binding …

Inhibitors of poly-ADP-ribose polymerase (PARP) family proteins are currently in clinical trials
as cancer therapeutics, yet the specificity of many of these compounds is unknown. Here …

Background: Estrogens exert their effects on target tissues by binding to a nuclear transcription
factor termed the estrogen receptor (ER). Previous structural studies have demonstrated …

Selective inhibitors could help unveil the mechanisms by which inhibition of poly(ADP-ribose)
polymerases (PARPs) elicits clinical benefits in cancer therapy. We profiled 10 clinical …

Background Steroidogenic acute regulatory (StAR) protein related lipid transfer (START)
domains are small globular modules that form a cavity where lipids and lipid hormones bind. …

ADP-ribosyltransferases (ARTs) catalyze the transfer of ADP-ribose from NAD + onto
substrates. Some ARTs generate in an iterative process ADP-ribose polymers that serve as …

DEAD-box RNA helicases play various, often critical, roles in all processes where RNAs are
involved. Members of this family of proteins are linked to human disease, including cancer …

Protein ADP-ribosylation is a reversible post-translational modification that regulates important
cellular functions. The identification of modified proteins has proven challenging and has …

DNA-encoded chemical libraries are increasingly used in pharmaceutical research because
they enable the rapid discovery of synthetic protein ligands. Here we explored whether …

Despite the immense importance of enzyme–substrate reactions, there is a lack of general
and unbiased tools for identifying and prioritizing substrate proteins that are modified by the …