What is normal trauma healing and what is complex regional pain syndrome I? An analysis of clinical and experimental biomarkers

C Dietz, M Müller, AK Reinhold, L Karch, B Schwab… - Pain, 2019 - journals.lww.com
Complex regional pain syndrome (CRPS) typically develops after fracture or trauma. Many
of the studies so far have analyzed clinical and molecular markers of CRPS in comparison …

[HTML][HTML] Community-level prevalence of epilepsy and of neurocysticercosis among people with epilepsy in the Balaka district of Malawi: A cross-sectional study

…, V Schmidt, H Carabin, AK Reinhold… - PLoS Neglected …, 2022 - journals.plos.org
Background Epilepsy and neurocysticercosis (NCC) prevalence estimates in sub-Saharan
Africa are still scarce but show important variation due to the population studied and different …

[HTML][HTML] Quantitative and microstructural changes of the blood-nerve barrier in peripheral neuropathy

AK Reinhold, J Schwabe, TJ Lux, E Salvador… - Frontiers in …, 2018 - frontiersin.org
Peripheral neuropathy is accompanied by changes in the neuronal environment. The blood-nerve
barrier (BNB) is crucial in protecting the neural homeostasis: Tight junctions (TJ) seal …

[HTML][HTML] Neurofilament light chain levels indicate acute axonal damage under bortezomib treatment

…, H Stengel, X Zhou, H Einsele, AK Reinhold… - Journal of …, 2023 - Springer
Introduction Bortezomib (BTZ) is a selective and reversible proteasome inhibitor and first
line treatment for multiple myeloma (MM). One of the side effects is BTZ-induced peripheral …

[HTML][HTML] Systemic inflammatory markers in patients with polyneuropathies

…, A Neumann, N Cebulla, AK Reinhold… - Frontiers in …, 2023 - frontiersin.org
Introduction In patients with peripheral neuropathies (PNP), neuropathic pain is present in
50% of the cases, independent of the etiology. The pathophysiology of pain is poorly …

MicroRNA‐21‐5p functions via RECK/MMP9 as a proalgesic regulator of the blood nerve barrier in nerve injury

AK Reinhold, SM Krug, E Salvador… - Annals of the New …, 2022 - Wiley Online Library
Both nerve injury and complex regional pain syndrome (CRPS) can result in chronic pain. In
traumatic neuropathy, the blood nerve barrier (BNB) shielding the nerve is impaired—partly …

Analgesic drug delivery via recombinant tissue plasminogen activator and microRNA-183-triggered opening of the blood-nerve barrier

S Yang, SM Krug, J Heitmann, L Hu, AK Reinhold… - Biomaterials, 2016 - Elsevier
The peripheral nerve contains three barriers which include the blood-nerve barrier consisting
of endoneurial vessels and the perineurium as well as autotypic junctions in Schwann cells…

[HTML][HTML] Microvascular barrier protection by microRNA-183 via FoxO1 repression: a pathway disturbed in neuropathy and complex regional pain syndrome

AK Reinhold, E Salvador, CY Förster, F Birklein… - The Journal of …, 2022 - Elsevier
Blood nerve barrier disruption and edema are common in neuropathic pain as well as in
complex regional pain syndrome (CRPS). MicroRNAs (miRNA) are epigenetic multitarget …

[HTML][HTML] Tissue plasminogen activator and neuropathy open the blood-nerve barrier with upregulation of microRNA-155-5p in male rats

AK Reinhold, S Yang, JTC Chen, L Hu… - … Et Biophysica Acta (BBA …, 2019 - Elsevier
The blood-nerve barrier (BNB) consisting of the perineurium and endoneurial vessels is
sealed by tight junction proteins. BNB alterations are a crucial factor in the pathogenesis of …

Molecular and clinical markers of pain relief in complex regional pain syndrome: an observational study

AK Reinhold, GK Kindl, C Dietz, N Scheu… - … Journal of Pain, 2023 - Wiley Online Library
Ann Kristin Reinhold designed the study, performed the statistical analysis and wrote the
manuscript, Gudrun-Karin Kindl performed the statistical analysis, Christopher Dietz conducted …