Engineered gene drives — the process of stimulating the biased inheritance of specific genes
— have the potential to enable the spread of desirable genes throughout wild populations …

Background Respiratory disease is a major cause of morbidity and mortality; however,
surveillance for circulating respiratory viruses is passive and biased. Wastewater-based …

The recent development of a CRISPR-Cas9-based homing system for the suppression of
Anopheles gambiae is encouraging; however, with current designs, the slow emergence of …

Synthetic gene drive systems possess enormous potential to replace, alter, or suppress wild
populations of significant disease vectors and crop pests; however, their utility in diverse …

With dengue virus (DENV) becoming endemic in tropical and subtropical regions worldwide,
there is a pressing global demand for effective strategies to control the mosquitoes that …

Recent Zika virus (ZIKV) outbreaks have highlighted the necessity for development of novel
vector control strategies to combat arboviral transmission, including genetic versions of the …

CRISPR-based gene-drive systems, which copy themselves via gene conversion mediated
by the homology-directed repair (HDR) pathway, have the potential to revolutionize vector …

Scientists are rapidly developing synthetic gene drive elements intended for release into
natural populations. These are intended to control or eradicate disease vectors and pests, or to …

CRISPR-Cas9-based gene drive systems possess the inherent capacity to spread progressively
throughout target populations. Here we describe two self-copying (or active) guide RNA-…

Replacement of wild insect populations with transgene-bearing individuals unable to transmit
disease or survive under specific environmental conditions using gene drive provides a …