[HTML][HTML] A framework for clinical cancer subtyping from nucleosome profiling of cell-free DNA

…, RD Patton, N De Sarkar, KA Collier, ACH Hoge… - Nature …, 2022 - nature.com
Cell-free DNA (cfDNA) has the potential to inform tumor subtype classification and help guide
clinical precision oncology. Here we develop Griffin, a framework for profiling nucleosome …

CDK12-Mutated Prostate Cancer: Clinical Outcomes With Standard Therapies and Immune Checkpoint Blockade

…, LC Brown, RR McKay, T Dorff, ACH Hoge… - JCO precision …, 2020 - ascopubs.org
PURPOSE Translational studies have shown that CDK12 mutations may delineate an
immunoresponsive subgroup of prostate cancer, characterized by high neo-antigen burden. Given …

[HTML][HTML] DNA-based copy number analysis confirms genomic evolution of PDX models

ACH Hoge, M Getz, A Zimmer, M Ko, L Raz… - NPJ Precision …, 2022 - nature.com
Genomic evolution of patient-derived xenografts (PDXs) may lead to their gradual divergence
away of their tumors of origin. We previously reported the genomic evolution of the copy …

[HTML][HTML] Patterns of structural variation define prostate cancer across disease states

M Zhou, M Ko, ACH Hoge, K Luu, Y Liu, ML Russell… - JCI insight, 2022 - ncbi.nlm.nih.gov
The complex genomic landscape of prostate cancer evolves across disease states under
therapeutic pressure directed toward inhibiting androgen receptor (AR) signaling. While …

[HTML][HTML] Non-responder phenotype reveals apparent microbiome-wide antibiotic tolerance in the murine gut

C Diener, ACH Hoge, SM Kearney… - Communications …, 2021 - nature.com
Broad spectrum antibiotics cause both transient and lasting damage to the ecology of the
gut microbiome. Antibiotic-induced loss of gut bacterial diversity has been linked to …

Publisher Correction: DNA-based copy number analysis confirms genomic evolution of PDX models

ACH Hoge, M Getz, A Zimmer, M Ko, L Raz… - NPJ Precision …, 2022 - ncbi.nlm.nih.gov
Anna CH Hoge, # 1 Michal Getz, # 2 Anat Zimmer, 1 Minjeong Ko, 1 Linoy Raz, 2
Rameen Beroukhim, 3, 4, 5 Todd R. Golub, 3, 4, 5 Gavin Ha, corresponding author 1 and …

Non-responder phenotype reveals microbiome-wide antibiotic resistance in the murine gut

C Diener, ACH Hoge, SM Kearney, SE Erdman… - bioRxiv, 2019 - biorxiv.org
Broad spectrum antibiotics can cause both transient and lasting damage to the ecology of
the gut microbiome. Loss of gut bacterial diversity has been linked to immune dysregulation …

Author Correction: A framework for clinical cancer subtyping from nucleosome profiling of cell-free DNA

…, N De Sarkar, KA Collier, ACH Hoge… - nature …, 2023 - ncbi.nlm.nih.gov
Anna-Lisa Doebley, 1, 2, 3 Minjeong Ko, 1 Hanna Liao, 2, 4 A. Eden Cruikshank, 1, 2
Katheryn Santos, 5 Caroline Kikawa, 3 Joseph B. Hiatt, 1, 6 Robert D. … Collier, 7 Anna CH …

Somatic mutation but not aneuploidy differentiates lung cancer in never-smokers and smokers

S Moorthi, A Paguirigan, M Ko, M Pettinger, ACH Hoge… - bioRxiv, 2023 - biorxiv.org
Lung cancer in never-smokers disproportionately affects older women. To understand the
mutational landscape of this cohort, we performed detailed genome characterization of 73 …

[HTML][HTML] CAMELS-CH: hydro-meteorological time series and landscape attributes for 331 catchments in hydrologic Switzerland

M Höge, M Kauzlaric, R Siber… - Earth System …, 2023 - essd.copernicus.org
We present CAMELS-CH (Catchment Attributes and MEteorology for large-sample Studies -
Switzerland), a large-sample hydro-meteorological data set for hydrological Switzerland in …