Treatment of solid cancers with chimeric antigen receptor (CAR) T cells is plagued by the
lack of ideal target antigens that are both absolutely tumor specific and homogeneously …

BACKGROUND: Mutations in the human filaggrin gene (FLG) are associated with atopic
dermatitis (AD) and are presumed to provoke a barrier abnormality. Yet additional acquired …

To determine whether pigment type determines differences in epidermal function, we studied
stratum corneum (SC) pH, permeability barrier homeostasis, and SC integrity in three …

Cornification and epidermal barrier defects are associated with a number of clinically diverse
skin disorders. However, a suitable in vitro model for studying normal barrier function and …

Gold nanoparticles (GNPs) can be used as carriers of a variety of therapeutics. Ideally, drugs
are released in the target cells in response to cell specific intracellular triggers. In this study, …

Mutations in Ras family proteins are implicated in 33% of human cancers, but direct
pharmacological inhibition of Ras mutants remains challenging. As an alternative to direct inhibition, …

Humans with darkly pigmented skin display superior permeability barrier function in comparison
with humans with lightly pigmented skin. The reduced pH of the stratum corneum (SC) …

Extracellular Ca 2+ (Ca 2+ o ) is a crucial regulator of epidermal homeostasis and its receptor,
the Ca 2+ -sensing receptor (CaSR), conveys the Ca 2+ o signals to promote keratinocyte …

The corneocyte lipid envelope (CLE), a monolayer of ω-hydroxyceramides whose function(s)
remain(s) uncertain, is absent in patients with autosomal recessive congenital ichthyoses …

Glioblastoma multiforme is the most malignant type of primary brain tumor with a poor prognosis.
These tumors consist of a heterogeneous population of malignant cells, including well-…