An ever-increasing demand for novel antimicrobials to treat life-threatening infections caused
by the global spread of multidrug-resistant bacterial pathogens stands in stark contrast to …

In this review, a general introduction to fragment-based drug design and the underlying
concepts is given. General considerations and methodologies ranging from library selection/…

Dynamic combinatorial chemistry (DCC) has emerged as a powerful strategy to identify
ligands for biological targets given that it enables the target to direct the synthesis and …

In light of the global antimicrobial-resistance crisis, there is an urgent need for novel bacterial
targets and antibiotics with novel modes of action. It has been shown that Pseudomonas …

Drug‐discovery research in the past decade has seen an increased selection of targets with
phosphate recognition sites, such as protein kinases and phosphatases, in the past decade. …

Neuroinflammation is an important contributor to Alzheimer9s disease (AD) pathogenesis,
as underscored by the recent identification of immune-related genetic risk factors for AD, …

Inherently complex, lignin-derived aromatic monomers comprising valuable structural moieties
present in many pharmaceuticals would serve as ideal substrates for the construction of …

Abstract Structure‐based design (SBD) can be used for the design and/or optimization of
new inhibitors for a biological target. Whereas de novo SBD is rarely used, most reports on …

Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …

To win the battle against resistant, pathogenic bacteria, novel classes of anti-infectives and
targets are urgently needed. Bacterial uptake, distribution, metabolic and efflux pathways of …