User profiles for Anna Konstorum
Anna KonstorumInstitute for Defense Analyses Verified email at super.org Cited by 1427 |
Large-Scale in Silico and Microarray-Based Identification of Direct 1,25-Dihydroxyvitamin D3 Target Genes
…, Y Nagai, V Bourdeau, A Konstorum… - Molecular …, 2005 - academic.oup.com
1α,25-Dihydroxyvitamin D 3 [1,25(OH) 2 D 3 ] regulates calcium homeostasis and controls
cellular differentiation and proliferation. The vitamin D receptor (VDR) is a ligand-regulated …
cellular differentiation and proliferation. The vitamin D receptor (VDR) is a ligand-regulated …
Stearoyl-CoA desaturase 1 protects ovarian cancer cells from ferroptotic cell death
L Tesfay, BT Paul, A Konstorum, Z Deng, AO Cox… - Cancer research, 2019 - AACR
The combination of SCD1 inhibitors and ferroptosis inducers may provide a new therapeutic
strategy for the treatment of ovarian cancer patients. See related commentary by Carbone …
strategy for the treatment of ovarian cancer patients. See related commentary by Carbone …
Addressing current challenges in cancer immunotherapy with mathematical and computational modelling
A Konstorum, AT Vella, AJ Adler… - Journal of The …, 2017 - royalsocietypublishing.org
The goal of cancer immunotherapy is to boost a patient's immune response to a tumour. Yet,
the design of an effective immunotherapy is complicated by various factors, including a …
the design of an effective immunotherapy is complicated by various factors, including a …
[PDF][PDF] Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients
The IMPACC cohort, composed of >1,000 hospitalized COVID-19 participants, contains five
illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1…
illness trajectory groups (TGs) during acute infection (first 28 days), ranging from milder (TG1…
Contribution of three-dimensional architecture and tumor-associated fibroblasts to hepcidin regulation in breast cancer
N Blanchette-Farra, D Kita, A Konstorum, L Tesfay… - Oncogene, 2018 - nature.com
Hepcidin is a peptide hormone that negatively regulates iron efflux and plays an important
role in controlling the growth of breast tumors. In patients with breast cancer, the combined …
role in controlling the growth of breast tumors. In patients with breast cancer, the combined …
Feedback regulation in a cancer stem cell model can cause an allee effect
The exact mechanisms of spontaneous tumor remission or complete response to treatment
are phenomena in oncology that are not completely understood. We use a concept from …
are phenomena in oncology that are not completely understood. We use a concept from …
[HTML][HTML] Systems biology of ferroptosis: A modeling approach
A Konstorum, L Tesfay, BT Paul, FM Torti… - Journal of theoretical …, 2020 - Elsevier
Ferroptosis is a recently discovered form of iron-dependent regulated cell death (RCD) that
occurs via peroxidation of phospholipids containing polyunsaturated fatty acid (PUFA) …
occurs via peroxidation of phospholipids containing polyunsaturated fatty acid (PUFA) …
Neoantigens retention in patient derived xenograft models mediates autologous T cells activation in ovarian cancer
Ovarian cancer (OC) has an overall modest number of mutations that facilitate a functional
immune infiltrate able to recognize tumor mutated antigens, or neoantigens. Although patient-…
immune infiltrate able to recognize tumor mutated antigens, or neoantigens. Although patient-…
Activation of the HGF/c-Met axis in the tumor microenvironment: A multispecies model
A Konstorum, JS Lowengrub - Journal of theoretical biology, 2018 - Elsevier
The tumor microenvironment is an integral component in promoting tumor development.
Cancer-associated fibroblasts (CAFs), which reside in the tumor stroma, produce Hepatocyte …
Cancer-associated fibroblasts (CAFs), which reside in the tumor stroma, produce Hepatocyte …
Three-dimensional spatiotemporal modeling of colon cancer organoids reveals that multimodal control of stem cell self-renewal is a critical determinant of size and …
We develop a three-dimensional multispecies mathematical model to simulate the growth of
colon cancer organoids containing stem, progenitor and terminally differentiated cells, as a …
colon cancer organoids containing stem, progenitor and terminally differentiated cells, as a …