Increased production of L-serine in Escherichia coli through adaptive laboratory evolution

H Mundhada, JM Seoane, K Schneider, A Koza… - Metabolic …, 2017 - Elsevier
L-serine is a promising building block biochemical with a high theoretical production yield
from glucose. Toxicity of L-serine is however prohibitive for high-titer production in E. coli. Here…

[HTML][HTML] Multi-omics quantification of species variation of Escherichia coli links molecular features with strain phenotypes

JM Monk, A Koza, MA Campodonico, D Machado… - Cell systems, 2016 - cell.com
Escherichia coli strains are widely used in academic research and biotechnology. New
technologies for quantifying strain-specific differences and their underlying contributing factors …

[HTML][HTML] Adaptation of the autotrophic acetogen Sporomusa ovata to methanol accelerates the conversion of CO2 to organic products

PL Tremblay, D Höglund, A Koza, I Bonde, T Zhang - Scientific reports, 2015 - nature.com
Acetogens are efficient microbial catalysts for bioprocesses converting C1 compounds into
organic products. Here, an adaptive laboratory evolution approach was implemented to …

Characterization of a novel air–liquid interface biofilm of Pseudomonas fluorescens SBW25

A Koza, PD Hallett, CD Moon, AJ Spiers - Microbiology, 2009 - microbiologyresearch.org
Pseudomonads are able to form a variety of biofilms that colonize the air–liquid (A–L)
interface of static liquid microcosms, and differ in matrix composition, strength, resilience and …

[HTML][HTML] Laboratory evolution reveals general and specific tolerance mechanisms for commodity chemicals

…, K Chekina, E Özdemir, I Bonde, A Koza… - Metabolic …, 2023 - Elsevier
Although strain tolerance to high product concentrations is a barrier to the economically
viable biomanufacturing of industrial chemicals, chemical tolerance mechanisms are often …

Rapid resistome mapping using nanopore sequencing

…, W van Schaik, A Koza… - Nucleic acids …, 2017 - academic.oup.com
The emergence of antibiotic resistance in human pathogens has become a major threat to
modern medicine. The outcome of antibiotic treatment can be affected by the composition of …

Genome‐wide identification of tolerance mechanisms toward p‐coumaric acid in Pseudomonas putida

…, K Bojanovič, RM Lennen, A Koza… - Biotechnology and …, 2018 - Wiley Online Library
The soil bacterium Pseudomonas putida KT2440 has gained increasing biotechnological
interest due to its ability to tolerate different types of stress. Here, the tolerance of P. putida …

[HTML][HTML] EasyCloneMulti: A Set of Vectors for Simultaneous and Multiple Genomic Integrations in Saccharomyces cerevisiae

…, KR Kildegaard, MJ Herrgård, K Schneider, A Koza… - PLoS …, 2016 - journals.plos.org
Saccharomyces cerevisiae is widely used in the biotechnology industry for production of
ethanol, recombinant proteins, food ingredients and other chemicals. In order to generate highly …

Environmental modification and niche construction: developing O2 gradients drive the evolution of the Wrinkly Spreader

A Koza, O Moshynets, W Otten, AJ Spiers - The ISME journal, 2011 - academic.oup.com
The evolutionary success of the novel Wrinkly Spreader (WS) genotypes in diversifying
Pseudomonas fluorescens SBW25 populations in static liquid microcosms has been attributed to …

[HTML][HTML] Ethanol-lactate transition of Lachancea thermotolerans is linked to nitrogen metabolism

…, SN Mendoza, A Haver, K Al-Nakeeb, A Koza… - Food …, 2023 - Elsevier
Climate change increases sugar content in grapes, resulting in unwanted increase in
ethanol content of wine. Lachancea thermotolerans ferments glucose and fructose into both …