Increased production of L-serine in Escherichia coli through adaptive laboratory evolution
H Mundhada, JM Seoane, K Schneider, A Koza… - Metabolic …, 2017 - Elsevier
L-serine is a promising building block biochemical with a high theoretical production yield
from glucose. Toxicity of L-serine is however prohibitive for high-titer production in E. coli. Here…
from glucose. Toxicity of L-serine is however prohibitive for high-titer production in E. coli. Here…
[HTML][HTML] Multi-omics quantification of species variation of Escherichia coli links molecular features with strain phenotypes
Escherichia coli strains are widely used in academic research and biotechnology. New
technologies for quantifying strain-specific differences and their underlying contributing factors …
technologies for quantifying strain-specific differences and their underlying contributing factors …
[HTML][HTML] Adaptation of the autotrophic acetogen Sporomusa ovata to methanol accelerates the conversion of CO2 to organic products
PL Tremblay, D Höglund, A Koza, I Bonde, T Zhang - Scientific reports, 2015 - nature.com
Acetogens are efficient microbial catalysts for bioprocesses converting C1 compounds into
organic products. Here, an adaptive laboratory evolution approach was implemented to …
organic products. Here, an adaptive laboratory evolution approach was implemented to …
Characterization of a novel air–liquid interface biofilm of Pseudomonas fluorescens SBW25
Pseudomonads are able to form a variety of biofilms that colonize the air–liquid (A–L)
interface of static liquid microcosms, and differ in matrix composition, strength, resilience and …
interface of static liquid microcosms, and differ in matrix composition, strength, resilience and …
[HTML][HTML] Laboratory evolution reveals general and specific tolerance mechanisms for commodity chemicals
…, K Chekina, E Özdemir, I Bonde, A Koza… - Metabolic …, 2023 - Elsevier
Although strain tolerance to high product concentrations is a barrier to the economically
viable biomanufacturing of industrial chemicals, chemical tolerance mechanisms are often …
viable biomanufacturing of industrial chemicals, chemical tolerance mechanisms are often …
Rapid resistome mapping using nanopore sequencing
…, W van Schaik, A Koza… - Nucleic acids …, 2017 - academic.oup.com
The emergence of antibiotic resistance in human pathogens has become a major threat to
modern medicine. The outcome of antibiotic treatment can be affected by the composition of …
modern medicine. The outcome of antibiotic treatment can be affected by the composition of …
Genome‐wide identification of tolerance mechanisms toward p‐coumaric acid in Pseudomonas putida
…, K Bojanovič, RM Lennen, A Koza… - Biotechnology and …, 2018 - Wiley Online Library
The soil bacterium Pseudomonas putida KT2440 has gained increasing biotechnological
interest due to its ability to tolerate different types of stress. Here, the tolerance of P. putida …
interest due to its ability to tolerate different types of stress. Here, the tolerance of P. putida …
[HTML][HTML] EasyCloneMulti: A Set of Vectors for Simultaneous and Multiple Genomic Integrations in Saccharomyces cerevisiae
…, KR Kildegaard, MJ Herrgård, K Schneider, A Koza… - PLoS …, 2016 - journals.plos.org
Saccharomyces cerevisiae is widely used in the biotechnology industry for production of
ethanol, recombinant proteins, food ingredients and other chemicals. In order to generate highly …
ethanol, recombinant proteins, food ingredients and other chemicals. In order to generate highly …
Environmental modification and niche construction: developing O2 gradients drive the evolution of the Wrinkly Spreader
The evolutionary success of the novel Wrinkly Spreader (WS) genotypes in diversifying
Pseudomonas fluorescens SBW25 populations in static liquid microcosms has been attributed to …
Pseudomonas fluorescens SBW25 populations in static liquid microcosms has been attributed to …
[HTML][HTML] Ethanol-lactate transition of Lachancea thermotolerans is linked to nitrogen metabolism
…, SN Mendoza, A Haver, K Al-Nakeeb, A Koza… - Food …, 2023 - Elsevier
Climate change increases sugar content in grapes, resulting in unwanted increase in
ethanol content of wine. Lachancea thermotolerans ferments glucose and fructose into both …
ethanol content of wine. Lachancea thermotolerans ferments glucose and fructose into both …