Glioblastoma (GBM) is the most common and aggressive primary brain tumor. To better
understand how GBM evolves, we analyzed longitudinal genomic and transcriptomic data from …

The inference of transcriptional networks that regulate transitions into physiological or
pathological cellular states remains a central challenge in systems biology. A mesenchymal …

The brain tumor glioblastoma multiforme (GBM) is among the most lethal forms of human
cancer. Here, we report that a small subset of GBMs (3.1%; 3 of 97 tumors examined) harbors …

Cell growth and differentiation are usually antagonistic. Proteins of the basic helix-loop-helix
(bHLH) family bind DNA and play important roles in the differentiation of specific cell types. …

In mammalian cells, Id proteins coordinate proliferation and differentiation. Id2 is a dominant-negative
antagonist of basic helix–loop–helix transcription factors and proteins of the …

A large body of evidence has been accumulated that demonstrates dominant effects of Id
proteins on different aspects of cellular growth. Generally, constitutive expression of Id not only …

The transcriptomic classification of glioblastoma (GBM) has failed to predict survival and
therapeutic vulnerabilities. A computational approach for unbiased identification of core …

In the developing nervous system, Id2 (inhibitor of DNA binding 2, also known as inhibitor of
differentiation 2) enhances cell proliferation, promotes tumour progression and inhibits the …

Glioblastomas are incurable tumors infiltrating the brain. A subpopulation of glioblastoma
cells forms a functional and therapy-resistant tumor cell network interconnected by tumor …

The factors driving therapy resistance in diffuse glioma remain poorly understood. To
identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA …