Damage associated molecular patterns (DAMPs) are intracellular molecules released from
infected or injured cells to activate inflammatory and reparatory responses. One of the most …

Objectives To define guidelines for BK polyomavirus (BKPyV)-associated haemorrhagic
cystitis (BKPyV-HC) after paediatric and adult HSCT. Methods Review of English literature and …

In the tumor microenvironment (TME) ATP and its receptor P2X7 exert a pivotal influence on
cancer growth and tumor–host interactions. Here we analyzed the different effect of P2X7 …

Invasive fungal infections (IFIs) are an important cause of morbidity and mortality in
immunocompromised patients. Patients with hematological malignancies undergoing conventional …

Tumor growth and metastatic spreading are heavily affected by the P2X7 receptor as well
as microvesicles and exosomes release into the tumor microenvironment. P2X7 receptor …

Chemotherapy-induced immunogenic cell death can favor dendritic cell (DC) cross-priming
of tumor-associated antigens for T cell activation thanks to the release of damage-associated …

Acute myeloid leukemia (AML) is a common adult leukemia often arising from a preexistent
myelodysplastic syndrome (MDS). High mortality rates of AML are caused by relapse and …

The P2X7 receptor for extracellular ATP is a well-established mediator of tumoral development
and progression both in solid cancers and hematological malignancies. The human …

Astrocytes‐derived extracellular vesicles (EVs) are key players in glia‐neuron communication.
However, whether EVs interact with neurons at preferential sites and how EVs reach …

Highlights • Tumor bearing P2X7R null mice show increased and better performing Treg. •
Chemotactic gradient established by P2X7R ligands favors tumor infiltration by immune cells. …