Although androgen receptor (AR)-mediated signaling is central to prostate cancer, the ability
to modulate AR signaling states is limited. Here we establish a chemical genomic approach …

Triple-negative breast cancers (TNBCs) are defined by a lack of expression of estrogen,
progesterone, and HER2 receptors. Because of the absence of identified targets and targeted …

Using first-principles linear muffin-tin orbital density functional band structure calculations, the
ordering of the states in the wurtzite ZnO valence-band maximum, split by crystal-field and …

Neurodegeneration, a result of multiple dysregulatory events, is a lengthy multistep process
manifested by accrual of mutant variants and abnormal expression, posttranslational …

Most cancers are characterized by multiple molecular alterations, but identification of the key
proteins involved in these signaling pathways is currently beyond reach. We show that the …

Hsp90 is a molecular chaperone with important roles in regulating pathogenic transformation.
In addition to its well-characterized functions in malignancy, recent evidence from several …

Transient, multi-protein complexes are important facilitators of cellular functions. This
includes the chaperome, an abundant protein family comprising chaperones, co-chaperones, …

JAK2 kinase inhibitors were developed for the treatment of myeloproliferative neoplasms (MPNs),
following the discovery of activating JAK2 mutations in the majority of patients with …

The effect of nonspherical shape on the optical properties of semiconductor microcrystals
with a degenerate valence band has been theoretically studied. The asymmetry of …

The heat shock protein 90 (Hsp90) has a critical role in malignant transformation. Whereas
its ability to maintain the functional conformations of mutant and aberrant oncoproteins is …