Mitochondria have cell-type specific phenotypes, perform dozens of interconnected
functions and undergo dynamic and often reversible physiological recalibrations. Given their …

Research on human brain development and neurological diseases is limited by the lack of
advanced experimental in vitro models that truly recapitulate the complexity of the human …

Modeling Parkinson’s disease (PD) using advanced experimental in vitro models is a
powerful tool to study disease mechanisms and to elucidate unexplored aspects of this …

Patients with primary mitochondrial oxidative phosphorylation (OxPhos) defects present with
fatigue and multi-system disorders, are often lean, and die prematurely, but the mechanistic …

The brain and behavior are under energetic constraints, limited by mitochondrial energy
transformation capacity. However, the mitochondria-behavior relationship has not been …

Human midbrain-specific organoids (hMOs) serve as an experimental in vitro model for
studying the pathogenesis of Parkinson's disease (PD). In hMOs, neuroepithelial stem cells (…

Background The etiology of Parkinson's disease (PD) is only partially understood despite the
fact that environmental causes, risk factors, and specific gene mutations are contributors to …

Emerging evidence suggests that Parkinson's disease (PD), besides being an age-associated
disorder, might also have a neurodevelopment component. Disruption of mitochondrial …

Aging is a process of progressive change. To develop biological models of aging,
longitudinal datasets with high temporal resolution are needed. Here we report a multi-omics …

Introduction Brain organoids are highly complex multi-cellular tissue proxies, which have
recently risen as novel tools to study neurodegenerative diseases such as Parkinson's disease …