[HTML][HTML] PD-1 blockade restores helper activity of tumor-infiltrating, exhausted PD-1hiCD39+ CD4 T cells
CC Balança, A Salvioni, CM Scarlata, M Michelas… - JCI insight, 2021 - ncbi.nlm.nih.gov
Tumor antigen–specific CD4 T cells accumulate at tumor sites, evoking their involvement in
antitumor effector functions in situ. Contrary to CD8 cytotoxic T lymphocyte exhaustion, that of …
antitumor effector functions in situ. Contrary to CD8 cytotoxic T lymphocyte exhaustion, that of …
Distant antimetastatic effect of enterotropic colon cancer–derived α4β7+CD8+ T cells
…, N Thébault, F Lauzéral-Vizcaino, A Salvioni… - Science …, 2023 - science.org
Despite the high prognostic value of immune infiltrates in colorectal cancer (CRC), metastatic
disease remains resistant to immunotherapy by immune checkpoint blockade (ICB). Here, …
disease remains resistant to immunotherapy by immune checkpoint blockade (ICB). Here, …
[PDF][PDF] Robust control of a brain-persisting parasite through MHC I presentation by infected neurons
A Salvioni, M Belloy, A Lebourg, E Bassot… - Cell reports, 2019 - cell.com
Control of CNS pathogens by CD8 T cells is key to avoid fatal neuroinflammation. Yet, the
modalities of MHC I presentation in the brain are poorly understood. Here, we analyze the …
modalities of MHC I presentation in the brain are poorly understood. Here, we analyze the …
Screening for frailty in older adults using a postal questionnaire: Rationale, methods, and instruments validation of the INTER‐FRAIL study
…, F Profili, S Bandinelli, A Salvioni… - Journal of the …, 2014 - Wiley Online Library
Objectives To develop and test a postal screening questionnaire to intercept frailty in older
community‐dwelling individuals. Design A questionnaire was developed on the basis of …
community‐dwelling individuals. Design A questionnaire was developed on the basis of …
Profiling MHC II immunopeptidome of blood‐stage malaria reveals that cDC 1 control the functionality of parasite‐specific CD 4 T cells
In malaria, CD 4 Th1 and T follicular helper ( T FH ) cells are important for controlling parasite
growth, but Th1 cells also contribute to immunopathology. Moreover, various regulatory …
growth, but Th1 cells also contribute to immunopathology. Moreover, various regulatory …
[HTML][HTML] Circulating Exhausted PD-1+CD39+ Helper CD4 T Cells Are Tumor-Antigen-Specific and Predict Response to PD-1/PD-L1 Axis Blockade
…, M Michelas, CM Scarlata, A Salvioni… - Cancers, 2022 - mdpi.com
Simple Summary Not all cancer patients receiving immunotherapy by immune checkpoint
blockade experience a clinical benefit. Our study was aimed at identifying biomarkers that …
blockade experience a clinical benefit. Our study was aimed at identifying biomarkers that …
A virus hosted in malaria-infected blood protects against T cell-mediated inflammatory diseases by impairing DC function in a type I IFN-dependent manner
…, MF Wlodarczyk, M Benamar, E Bassot, A Salvioni… - MBio, 2020 - Am Soc Microbiol
Coinfections shape immunity and influence the development of inflammatory diseases, resulting
in detrimental or beneficial outcome. Coinfections with concurrent Plasmodium species …
in detrimental or beneficial outcome. Coinfections with concurrent Plasmodium species …
Postal screening can identify frailty and predict poor outcomes in older adults: longitudinal data from INTER-FRAIL study
…, S Bandinelli, M Razzanelli, A Salvioni… - Age and …, 2016 - academic.oup.com
Objective: identification of older individuals at risk for health-related adverse outcomes (HRAO)
is necessary for population-based preventive interventions. Aim of this study was to …
is necessary for population-based preventive interventions. Aim of this study was to …
A screening and comprehensive assessment programme aimed at secondary prevention of disability in community-dwelling frail older subjects: a pilot study
…, S Bandinelli, C Corridori, A Salvioni… - Epidemiologia e …, 2013 - europepmc.org
Objective to test a screening and comprehensive assessment procedures for frail elderly in
Tuscany (Central Italy) in the perspective of interventions to prevent disability. Design two-…
Tuscany (Central Italy) in the perspective of interventions to prevent disability. Design two-…
Adaptive immunity
N Blanchard, A Salvioni, EA Robey - Toxoplasma gondii, 2020 - Elsevier
This chapter summarizes our current understanding of how the adaptive immune system
recognizes and responds to Toxoplasma gondii infection. Following the first line of innate …
recognizes and responds to Toxoplasma gondii infection. Following the first line of innate …