Background Lysosomal dysfunction is thought to be a prominent feature in the pathogenetic
events leading to Parkinson’s disease (PD). This view is supported by the evidence that …

Background Reduced β‐glucocerebrosidase activity was observed in postmortem brains of
both GBA1 mutation carrier and noncarrier Parkinson's disease patients, suggesting that …

Mutations in the GBA gene, encoding the lysosomal hydrolase glucocerebrosidase (GCase),
are the most common known genetic risk factor for Parkinson’s disease (PD) and dementia …

Much effort has been devoted to the development of selective inhibitors of the LRRK2 as a
potential treatment for LRRK2 driven Parkinson's disease. In this study, we first compare the …

1. ABSTRACT Lysosomal alpha-mannosidase is ubiquitous in human tissues where is
expressed in two major forms, A and B that are the product of a single gene located on …

Introduction: Parkinson’s disease (PD) is a complex and phenotypically heterogeneous
neurodegenerative disease, for which the diagnosis is mainly based on clinical parameters (…

Evidence from family and twin studies points to a genetic contribution to the etiology of eating
disorders (EDs), confirmed by the association of several single nucleotide polymorphisms (…

Vitamin D3 has been described to have different extraskeletal roles by acting as parahormone
in obesity, diabetes, cancer, cognitive impairment, and dementia and to have important …

Neutral sphingomyelinase is known to be implicated in growth arrest, differentiation,
proliferation, and apoptosis. Although previous studies have reported the involvement of neutral …

Background Diet and obesity are recognized in the scientific literature as important risk
factors for cancer development and progression. Hypercholesterolemia facilitates lymphoma …