Stochastic transport through carbon nanotubes in lipid bilayers and live cell membranes

…, R Tunuguntla, LR Comolli, FI Allen, AV Shnyrova… - Nature, 2014 - nature.com
There is much interest in developing synthetic analogues of biological membrane channels
1 with high efficiency and exquisite selectivity for transporting ions and molecules. Bottom-up …

Lipid polymorphisms and membrane shape

VA Frolov, AV Shnyrova… - Cold Spring Harbor …, 2011 - cshperspectives.cshlp.org
Morphological plasticity of biological membrane is critical for cellular life, as cells need to
quickly rearrange their membranes. Yet, these rearrangements are constrained in two ways. …

Geometric catalysis of membrane fission driven by flexible dynamin rings

AV Shnyrova, PV Bashkirov, SA Akimov, TJ Pucadyil… - Science, 2013 - science.org
Biological membrane fission requires protein-driven stress. The guanosine triphosphatase (GTPase)
dynamin builds up membrane stress by polymerizing into a helical collar that …

A hemi-fission intermediate links two mechanistically distinct stages of membrane fission

JP Mattila, AV Shnyrova, AC Sundborger… - Nature, 2015 - nature.com
Fusion and fission drive all vesicular transport. Although topologically opposite, these
reactions pass through the same hemi-fusion/fission intermediate 1 , 2 , characterized by a ‘stalk’ …

NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress-induced mitochondrial fission

…, AV Shnyrova… - Proceedings of the …, 2021 - National Acad Sciences
Mitochondria form tubular networks that undergo coordinated cycles of fission and fusion.
Emerging evidence suggests that a direct yet unresolved interaction of the mechanoenzymatic …

Thermally induced conformational changes in horseradish peroxidase

DG Pina, AV Shnyrova, F Gavilanes… - European Journal of …, 2001 - Wiley Online Library
Detailed differential scanning calorimetry (DSC), steady‐state tryptophan fluorescence and
far‐UV and visible CD studies, together with enzymatic assays, were carried out to monitor …

[HTML][HTML] Dynamic constriction and fission of endoplasmic reticulum membranes by reticulon

…, PI Kuzmin, PV Bashkirov, AV Shnyrova… - Nature …, 2019 - nature.com
The endoplasmic reticulum (ER) is a continuous cell-wide membrane network. Network
formation has been associated with proteins producing membrane curvature and fusion, such as …

[HTML][HTML] Human ATG3 binding to lipid bilayers: role of lipid geometry, and electric charge

JH Hervás, A Landajuela, Z Antón, AV Shnyrova… - Scientific reports, 2017 - nature.com
Specific protein-lipid interactions lead to a gradual recruitment of AuTophaGy-related (ATG)
proteins to the nascent membrane during autophagosome (AP) formation. ATG3, a key …

Geometry of membrane fission

…, A Escalada, SA Akimov, AV Shnyrova - Chemistry and physics of …, 2015 - Elsevier
Cellular membranes define the functional geometry of intracellular space. Formation of new
membrane compartments and maintenance of complex organelles require division and …

Vesicle formation by self-assembly of membrane-bound matrix proteins into a fluidlike budding domain

AV Shnyrova, J Ayllon, II Mikhalyov, E Villar… - The Journal of cell …, 2007 - rupress.org
The shape of enveloped viruses depends critically on an internal protein matrix, yet it
remains unclear how the matrix proteins control the geometry of the envelope membrane. We …