Age-related macular degeneration (AMD) remains a major cause of blindness, with
dysfunction and loss of retinal pigment epithelium (RPE) central to disease progression. We …

Objective Integration of nutritional, microbial and inflammatory events along the gut-brain
axis can alter bowel physiology and organism behaviour. Colonic sensory neurons activate …

Induced pluripotent stem cells (iPSCs), and cells derived from them, have become key tools
for modeling biological processes, particularly in cell types that are difficult to obtain from …

Human genetic studies show that the voltage gated sodium channel 1.7 (Na v 1.7) is a key
molecular determinant of pain sensation. However, defining the Na v 1.7 contribution to …

The generation of human sensory neurons by directed differentiation of pluripotent stem cells
opens new opportunities for investigating the biology of pain. The inability to generate this …

The slow Wallerian degeneration (Wld S ) protein protects injured axons from degeneration.
This unusual chimeric protein fuses a 70–amino acid N-terminal sequence from the Ube4b …

Background Changes in gene expression are hallmarks of cellular differentiation. Sexual
differentiation in fission yeast (Schizosaccharomyces pombe) provides a model system for …

Key points Voltage‐gated sodium channels play a fundamental role in determining neuronal
excitability. Specifically, voltage‐gated sodium channel subtype Na V 1.7 is required for …

Background and Purpose TREK two‐pore‐domain potassium (K 2P ) channels play a critical
role in regulating the excitability of somatosensory nociceptive neurons and are important …

Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect
of cancer treatment, often associated with degeneration of sensory axons or their terminal …