SARS-CoV-2 productively infects human gut enterocytes

…, RBG Ravelli, J Paul van Schayck, AZ Mykytyn… - Science, 2020 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause coronavirus
disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the lungs …

Divergent SARS-CoV-2 Omicron–reactive T and B cell responses in COVID-19 vaccine recipients

…, D Geers, KS Schmitz, AZ Mykytyn… - Science …, 2022 - science.org
The severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) Omicron
variant is spreading rapidly, even in vaccinated individuals, raising concerns about immune …

Antigenic cartography of SARS-CoV-2 reveals that Omicron BA. 1 and BA. 2 are antigenically distinct

AZ Mykytyn, M Rissmann, A Kok, ME Rosu… - Science …, 2022 - science.org
The emergence and rapid spread of SARS-CoV-2 variants may affect vaccine efficacy
substantially. The Omicron variant termed BA.2, which differs substantially from BA.1 based on …

An organoid‐derived bronchioalveolar model for SARS‐CoV‐2 infection of human alveolar type II‐like cells

…, S Riesebosch, TI Breugem, AZ Mykytyn… - The EMBO …, 2021 - embopress.org
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes coronavirus
disease 2019 (COVID‐19), which may result in acute respiratory distress syndrome (ARDS), …

[PDF][PDF] Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection

…, I Bontjer, JA Burger, M Poniman, AZ Mykytyn… - Cell, 2021 - cell.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is continuing
to disrupt personal lives, global healthcare systems, and economies. Hence, there is an …

SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site

AZ Mykytyn, TI Breugem, S Riesebosch, D Schipper… - Elife, 2021 - elifesciences.org
Coronavirus entry is mediated by the spike protein that binds the receptor and mediates
fusion after cleavage by host proteases. The proteases that mediate entry differ between cell …

Susceptibility of rabbits to SARS-CoV-2

AZ Mykytyn, MM Lamers, NMA Okba… - Emerging Microbes & …, 2021 - Taylor & Francis
Transmission of severe acute respiratory coronavirus-2 (SARS-CoV-2) between livestock
and humans is a potential public health concern. We demonstrate the susceptibility of rabbits …

Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation

MM Lamers, AZ Mykytyn, TI Breugem, Y Wang, DC Wu… - Elife, 2021 - elifesciences.org
Virus propagation methods generally use transformed cell lines to grow viruses from clinical
specimens, which may force viruses to rapidly adapt to cell culture conditions, a process …

[HTML][HTML] A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses

…, J Zhang, J van der Vaart, AZ Mykytyn… - Nature …, 2021 - nature.com
Rapid identification of host genes essential for virus replication may expedite the generation
of therapeutic interventions. Genetic screens are often performed in transformed cell lines …

[HTML][HTML] Antigenic mapping of emerging SARS-CoV-2 omicron variants BM. 1.1. 1, BQ. 1.1, and XBB. 1

AZ Mykytyn, ME Rosu, A Kok, M Rissmann… - The Lancet …, 2023 - thelancet.com
Novel SARS-CoV-2 omicron variants, including BM. 1.1. 1, BQ. 1.1, and XBB. 1, continue to
emerge at an unprecedented rate, evading preexisting immunity from vaccination and …