SARS-CoV-2 productively infects human gut enterocytes
…, RBG Ravelli, J Paul van Schayck, AZ Mykytyn… - Science, 2020 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause coronavirus
disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the lungs …
disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the lungs …
Divergent SARS-CoV-2 Omicron–reactive T and B cell responses in COVID-19 vaccine recipients
…, D Geers, KS Schmitz, AZ Mykytyn… - Science …, 2022 - science.org
The severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) Omicron
variant is spreading rapidly, even in vaccinated individuals, raising concerns about immune …
variant is spreading rapidly, even in vaccinated individuals, raising concerns about immune …
Antigenic cartography of SARS-CoV-2 reveals that Omicron BA. 1 and BA. 2 are antigenically distinct
AZ Mykytyn, M Rissmann, A Kok, ME Rosu… - Science …, 2022 - science.org
The emergence and rapid spread of SARS-CoV-2 variants may affect vaccine efficacy
substantially. The Omicron variant termed BA.2, which differs substantially from BA.1 based on …
substantially. The Omicron variant termed BA.2, which differs substantially from BA.1 based on …
An organoid‐derived bronchioalveolar model for SARS‐CoV‐2 infection of human alveolar type II‐like cells
…, S Riesebosch, TI Breugem, AZ Mykytyn… - The EMBO …, 2021 - embopress.org
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes coronavirus
disease 2019 (COVID‐19), which may result in acute respiratory distress syndrome (ARDS), …
disease 2019 (COVID‐19), which may result in acute respiratory distress syndrome (ARDS), …
[PDF][PDF] Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 infection
…, I Bontjer, JA Burger, M Poniman, AZ Mykytyn… - Cell, 2021 - cell.com
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is continuing
to disrupt personal lives, global healthcare systems, and economies. Hence, there is an …
to disrupt personal lives, global healthcare systems, and economies. Hence, there is an …
SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site
AZ Mykytyn, TI Breugem, S Riesebosch, D Schipper… - Elife, 2021 - elifesciences.org
Coronavirus entry is mediated by the spike protein that binds the receptor and mediates
fusion after cleavage by host proteases. The proteases that mediate entry differ between cell …
fusion after cleavage by host proteases. The proteases that mediate entry differ between cell …
Susceptibility of rabbits to SARS-CoV-2
Transmission of severe acute respiratory coronavirus-2 (SARS-CoV-2) between livestock
and humans is a potential public health concern. We demonstrate the susceptibility of rabbits …
and humans is a potential public health concern. We demonstrate the susceptibility of rabbits …
Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation
Virus propagation methods generally use transformed cell lines to grow viruses from clinical
specimens, which may force viruses to rapidly adapt to cell culture conditions, a process …
specimens, which may force viruses to rapidly adapt to cell culture conditions, a process …
[HTML][HTML] A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses
…, J Zhang, J van der Vaart, AZ Mykytyn… - Nature …, 2021 - nature.com
Rapid identification of host genes essential for virus replication may expedite the generation
of therapeutic interventions. Genetic screens are often performed in transformed cell lines …
of therapeutic interventions. Genetic screens are often performed in transformed cell lines …
[HTML][HTML] Antigenic mapping of emerging SARS-CoV-2 omicron variants BM. 1.1. 1, BQ. 1.1, and XBB. 1
AZ Mykytyn, ME Rosu, A Kok, M Rissmann… - The Lancet …, 2023 - thelancet.com
Novel SARS-CoV-2 omicron variants, including BM. 1.1. 1, BQ. 1.1, and XBB. 1, continue to
emerge at an unprecedented rate, evading preexisting immunity from vaccination and …
emerge at an unprecedented rate, evading preexisting immunity from vaccination and …