Hematopoietic stem cells (HSCs) arise, self-renew, or give rise to all hematopoietic lineages
through the effects of transcription factors activated by signaling cascades. Lyl-1 encodes a …

The blastema is a mass of progenitor cells that enables regeneration of amputated
salamander limbs or fish fins. Methodology to label and track blastemal cell progeny has been …

Taste buds, the taste sensory organs, are conserved in vertebrates and composed of
distinct cell types, including taste receptor, basal/presynaptic and support cells. Here, we …

The TAL-1/SCL and LYL-1 genes encode two closely related basic helix–loop–helix
transcription factors involved in child T-acute lymphoblastic leukemia through chromosomal …

Taste buds are sensory organs in jawed vertebrates, composed of distinct cell types that
detect and transduce specific taste qualities. Taste bud cells differentiate from oropharyngeal …

During ontogeny, macrophage populations emerge in the Yolk Sac (YS) via two distinct
progenitor waves, prior to hematopoietic stem cell development. Macrophage progenitors from …

Objective LYL-1 is a transcription factor containing a basic helix-loop-helix motif closely
related to SCL/TAL-1, a regulator of erythroid differentiation. Because LYL-1 is expressed in …

Key points: 1-Lyl-1 expression marks yolk sac macrophages and brain macrophage/microglia/BAM.
2-Lyl-1 deficiency impairs primitive macrophage development and leads to the up-…

It is now well established that in all vertebrate species the development of a functional
haematopoietic system requires the sequential contribution of two independently generated pools …

… Authors: Soulika Marina1, Kaushik Anna-Lila1#, Mathieu Benjamin1#, Lourenço Raquel1¶§,
Komisarczuk Anna Z., Romano Sebastian Alejo1, Jouary Adrien1, Lardennois Alicia1 …