Although thousands of long noncoding RNAs (lncRNAs) have been discovered, very little is
known about their mode of action. Here we functionally characterize an E2F1-regulated …

Background Cells have evolved quality control mechanisms to ensure protein homeostasis
by detecting and degrading aberrant mRNAs and proteins. A common source of aberrant …

Makorins are evolutionary conserved proteins that contain C 3 H-type zinc finger modules
and a RING E3 ubiquitin ligase domain. In Drosophila, maternal Makorin 1 (Mkrn1) has been …

The experiments described here were designed, conducted and analyzed by me with the
following exceptions: Hong Han and Niankun Liu (McGill University) constructed the Mkrn1W …

Immune checkpoint inhibition suggests promising progress for the treatment of advanced
hepatocellular carcinoma (HCC). However, the underlying cellular mechanisms remain …

Prognosis of patients with advanced extrahepatic cholangiocarcinoma (eCCA) is poor. The
current standard first-line treatment is systemic chemotherapy (CT) with gemcitabine and a …

Background The pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
might be curtailed by vaccination. We assessed the safety, reactogenicity, and …

Background Older adults (aged ≥70 years) are at increased risk of severe disease and
death if they develop COVID-19 and are therefore a priority for immunisation should an …

The work included in this thesis was conducted within a joint research project in the laboratories
of Dr. Julian König and Dr. Petra Beli at the IMB in Mainz. Dr. Julian König and Dr. Petra …

Background The ChAdOx1 nCoV-19 (AZD1222) vaccine has been approved for emergency
use by the UK regulatory authority, Medicines and Healthcare products Regulatory Agency, …