Microglia are central to pathogenesis in many neurological conditions. Drugs targeting
colony-stimulating factor-1 receptor (CSF1R) to block microglial proliferation in preclinical …

The 21kD GTPase Rac is an evolutionarily ancient regulator of cell shape and behavior.
Rac2 is predominantly expressed in hematopoietic cells where it is essential for survival and …

Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane
receptor of the immunoglobulin superfamily that is secreted in a soluble (sTREM2) form. …

Macrophages measure the ‘eat-me’signal IgG to identify targets for phagocytosis. We wondered
if prior encounters with IgG influence macrophage appetite. IgG is recognized by the Fc …

Microglia are a fundamental component of pathogenesis in many neurological conditions
and have specialized functions that vary by disease stage or specific pathology. Drugs …

The ketogenic diet (KD) has long been used to treat intractable epilepsy when pharmacological
methods proved ineffective. It is a high fat, low carbohydrate, calorie restricted diet that …

… Annalise's intelligence, determination and abiding desire to protect people left out of the
American dream; it also reveals the pain and selfloathing that mars Annalise's emotional bond …

… Annalise’s intelligence, determination and abiding desire to protect people left out of the
American dream; it also reveals the pain and selfloathing that mars Annalise’s emotional bond …

Objective To determine the ability of CSF biomarkers to predict disease progression in
progressive supranuclear palsy (PSP). Methods We compared the ability of baseline CSF β-…