Phosphoglycerate dehydrogenase (PHGDH) catalyzes the committed step in de novo serine
biosynthesis. Paradoxically, PHGDH and serine synthesis are required in the presence of …

Malignant cells remodel their metabolism to meet the demands of uncontrolled cell proliferation.
These demands lead to differential requirements in energy, biosynthetic precursors, and …

Mechanistic target of rapamycin complex 1 (mTORC1) regulates cell growth and metabolism
in response to multiple nutrients, including the essential amino acid leucine 1 . Recent work …

Altered glucose metabolism is common in cancer. In this issue of Cancer Cell, Morita et al.
report new mouse models that express specific isoforms of pyruvate kinase to study glycolysis …

The small molecule erastin inhibits the cystine-glutamate antiporter, system x c - , which leads
to intracellular cysteine and glutathione depletion. This can cause ferroptosis, which is an …

Aerobic glycolysis or the Warburg effect (WE) is characterized by increased glucose uptake
and incomplete oxidation to lactate. Although the WE is ubiquitous, its biological role …

Plant‐based diets exclude or substantially limit the consumption of meat and animal products
and are of growing interest to many due to their sustainability and health benefits (Eshel et …

… 9 , Annamarie E Allen …

Metabolism is essential for life and is involved in disease. By studying metabolism, we can
understand basic cellular and organismal physiology, and try to modulate metabolism to treat …

Aerobic glycolysis or the Warburg Effect (WE) is characterized by increased glucose uptake
and incomplete oxidation to lactate. Although ubiquitous, the biological role of the WE …