Cell growth and proliferation require coordinated ribosomal biogenesis and translation.
Eukaryotic initiation factors (eIFs) control translation at the rate-limiting step of initiation 1 , 2 . So …

Myosin VI is the only myosin that moves toward the minus end of actin filaments, suggesting
a unique biological function. Here, we show that myosin VI is present in the nucleus of …

Breast cancer consists of highly heterogeneous tumors, whose cell of origin and driver
oncogenes are difficult to be uniquely defined. Here we report that MYC acts as tumor …

Eukaryotic ribosome biogenesis and translation are linked processes that limit the rate of
cell growth. Although ribosome biogenesis and translation are mainly controlled by distinct …

Eukaryotic Initiation Factor 6 (eIF6) controls translation by regulating 80S subunit formation.
eIF6 is overexpressed in tumors. Here, we demonstrate that eIF6 inactivation delays …

Insulin regulates glycaemia, lipogenesis and increases mRNA translation. Cells with reduced
eukaryotic initiation factor 6 (eIF6) do not increase translation in response to insulin. The …

Here we discuss the function of eukaryotic initiation factor 6 (eIF6; Tif6 in yeast). eIF6 binds
60S ribosomal subunits and blocks their joining to 40S. In this context, we propose that eIF6 …

Penicillium marneffei is an intracellular opportunistic fungus causing invasive mycosis in
AIDS patients. T cells and macrophages are important for protection in vivo. However, the role …

This study identifies a new multiple myeloma–specific tumor suppressor complex that regulates
autophagy and unconventional secretion, highlighting the sensitivity of multiple myeloma …

Ribosomes have been long considered as executors of the translational program. The fact
that ribosomes can control the translation of specific mRNAs or entire cellular programs is …