Astrocytes contribute to the formation, function, and plasticity of synapses. Their processes
enwrap the neuronal components of the tripartite synapse, and due to this close interaction …

Altered mesolimbic dopamine signaling has been widely implicated in addictive behavior.
For the most part, this work has focused on dopamine within the striatum, but there is …

Objective Astrocytes have gained attention as important players in neurological disease. In
line with their heterogeneous character, defects in specific astrocyte subtypes have been …

Objective Mucopolysaccharidosis type IIIA (MPSIIIA) caused by recessive SGSH variants
results in sulfamidase deficiency, leading to neurocognitive decline and death. No disease‐…

Glutamate homeostasis is an important determinant of health of the central nervous system (CNS).
Mitochondria play crucial roles in glutamate metabolism, especially in processes with …

Stem cell therapy has great prospects for brain white matter disorders, including the
genetically determined disorders called leukodystrophies. We focus on the devastating …

Vanishing white matter (VWM) is a fatal leukodystrophy caused by recessive mutations in
subunits of the eukaryotic translation initiation factor 2B. Currently, there are no effective …

Introduction Vanishing white matter (VWM) is a leukodystrophy that leads to neurological
dysfunction and early death. Astrocytes are indicated as therapeutic target, because of their …

Vanishing white matter (VWM) is a leukodystrophy caused by recessive variants in subunits
of eIF2B. At present, no curative treatment is available and patients often die at young age. …

Astrocytes gained attention as important players in neurological disease, including a number
of leukodystrophies. Several studies explored the generation of induced pluripotent stem …