The liver is the largest solid organ in the body, yet it remains incompletely characterized.
Here we present a spatial proteogenomic atlas of the healthy and obese human and murine …

Studies in Zucker diabetic fatty rats have led to the concept that chronically elevated free fatty
acid (FFA) levels can cause apoptosis of triglyceride-laden pancreatic β-cells as a result of …

Metabolic-associated fatty liver disease (MAFLD) represents a spectrum of disease states
ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). Hepatic macrophages, …

Background & Aims Hepatic stellate cell activation is a wound-healing response to liver
injury. However, continued activation of stellate cells during chronic liver damage causes …

We have previously observed that a 6-day exposure of human pancreatic islets to a combination
of cytokines (interleukin-1β 50 U/ml + tumour necrosis factor-α 1000 U/ml + interferon-γ …

This study demonstrates that rat islet beta cells constitutively express an apoptotic program
which is activated when mRNA or protein synthesis is blocked. Apoptotic beta cells were …

In a series of 22 pancreatic acinar cell carcinomas, including two acinar cystadenocarcinomas,
cellular differentiation was analyzed by immunocytochemistry and electron microscopy. …

Intraductal papillary mucinous neoplasms (IPMNs) and mucinous cystic neoplasms (MCNs)
are non-invasive neoplasms that are often observed in association with invasive pancreatic …

Angiogenesis contributes to the development of nonalcoholic steatohepatitis (NASH) and
promotes inflammation, fibrosis, and progression to hepatocellular carcinoma (HCC). …

Background Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal
tumors of the gastrointestinal tract. Surgical treatment is the only chance of cure for patients …