[PDF][PDF] CRY2 and FBXL3 cooperatively degrade c-MYC
AL Huber, SJ Papp, AB Chan, E Henriksson… - Molecular cell, 2016 - cell.com
For many years, a connection between circadian clocks and cancer has been postulated.
Here we describe an unexpected function for the circadian repressor CRY2 as a component of …
Here we describe an unexpected function for the circadian repressor CRY2 as a component of …
[PDF][PDF] p58IPK-mediated attenuation of the proapoptotic PERK-CHOP pathway allows malignant progression upon low glucose
AL Huber, J Lebeau, P Guillaumot, V Pétrilli, M Malek… - Molecular cell, 2013 - cell.com
As solid tumors expand, oxygen and nutrients become limiting owing to inadequate
vascularization and diffusion. How malignant cells cope with this potentially lethal metabolic stress …
vascularization and diffusion. How malignant cells cope with this potentially lethal metabolic stress …
DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization
SJ Papp, AL Huber, SD Jordan, A Kriebs, M Nguyen… - Elife, 2015 - elifesciences.org
10.7554/eLife.04883.001 The circadian transcriptional repressors cryptochrome 1 (Cry1)
and 2 (Cry2) evolved from photolyases, bacterial light-activated DNA repair enzymes. In this …
and 2 (Cry2) evolved from photolyases, bacterial light-activated DNA repair enzymes. In this …
In situ study of activation and de-activation of LSM fuel cell cathodes–Electrochemistry and surface analysis of thin-film electrodes
AK Huber, M Falk, M Rohnke, B Luerssen, M Amati… - Journal of catalysis, 2012 - Elsevier
The activation mechanism of the (ORR) on lanthanum strontium manganite (LSM) thin-film
electrodes is investigated by examining the electrochemical behavior with impedance …
electrodes is investigated by examining the electrochemical behavior with impedance …
In situ study of electrochemical activation and surface segregation of the SOFC electrode material La 0.75 Sr 0.25 Cr 0.5 Mn 0.5 O 3±δ
AK Huber, M Falk, M Rohnke, B Luerßen… - Physical Chemistry …, 2012 - pubs.rsc.org
Mixed-conducting perovskite-type electrodes which are used as cathodes in solid oxide fuel
cells (SOFCs) exhibit pronounced performance improvement after cathodic polarization. …
cells (SOFCs) exhibit pronounced performance improvement after cathodic polarization. …
[HTML][HTML] Current State of Dendritic Cell-Based Immunotherapy: Opportunities for in vitro Antigen Loading of Different DC Subsets?
A Huber, F Dammeijer, JGJV Aerts… - Frontiers in …, 2018 - frontiersin.org
Dendritic cell (DC) based cancer immunotherapy aims at the activation of the immune system,
and in particular tumor-specific cytotoxic T lymphocytes (CTLs) to eradicate the tumor. …
and in particular tumor-specific cytotoxic T lymphocytes (CTLs) to eradicate the tumor. …
[PDF][PDF] CRY1/2 selectively repress PPARδ and limit exercise capacity
…, D Duglan, W Fan, E Henriksson, AL Huber… - Cell metabolism, 2017 - cell.com
Cellular metabolite balance and mitochondrial function are under circadian control, but the
pathways connecting the molecular clock to these functions are unclear. Peroxisome …
pathways connecting the molecular clock to these functions are unclear. Peroxisome …
[HTML][HTML] FUS mislocalization and vulnerability to DNA damage in ALS patients derived hiPSCs and aging motoneurons
…, C Jacob, AK Lutz, J Bausinger, AK Huber… - Frontiers in cellular …, 2016 - frontiersin.org
Mutations within the FUS gene (Fused in Sarcoma) are known to cause Amyotrophic Lateral
Sclerosis (ALS), a neurodegenerative disease affecting upper and lower motoneurons. The …
Sclerosis (ALS), a neurodegenerative disease affecting upper and lower motoneurons. The …
[HTML][HTML] Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer
…, A Barrera, K Monkhorst, A Huber… - Nature …, 2021 - nature.com
The glucocorticoid receptor (GR) regulates gene expression, governing aspects of
homeostasis, but is also involved in cancer. Pharmacological GR activation is frequently used to …
homeostasis, but is also involved in cancer. Pharmacological GR activation is frequently used to …
Circadian repressors CRY1 and CRY2 broadly interact with nuclear receptors and modulate transcriptional activity
…, D Duglan, SJ Papp, AL Huber… - Proceedings of the …, 2017 - National Acad Sciences
Nuclear hormone receptors (NRs) regulate physiology by sensing lipophilic ligands and
adapting cellular transcription appropriately. A growing understanding of the impact of circadian …
adapting cellular transcription appropriately. A growing understanding of the impact of circadian …