Circulating tumour DNA (ctDNA) can be used to detect and profile residual tumour cells
persisting after curative intent therapy 1 . The study of large patient cohorts incorporating …

Herpes simplex virus 1 (HSV-1) is an important human pathogen and a paradigm for virus-induced
host shut-off. Here we show that global changes in transcription and RNA processing …

Importance Papillary renal cell carcinoma (PRCC) is the most common type of non–clear
cell RCC. Because some cases of PRCC areMET-driven, MET inhibition could be a targeted …

Ribosome profiling has been used to predict thousands of short open reading frames (sORFs)
in eukaryotic cells, but it suffers from substantial levels of noise. PRICE ( https://github.com/…

RNA synthesis and decay rates determine the steady-state levels of cellular RNAs.
Metabolic tagging of newly transcribed RNA by 4-thiouridine (4sU) can reveal the relative …

The predicted 80 open reading frames (ORFs) of herpes simplex virus 1 (HSV-1) have been
intensively studied for decades. Here, we unravel the complete viral transcriptome and …

Lytic herpes simplex virus 1 (HSV-1) infection triggers disruption of transcription termination
(DoTT) of most cellular genes, resulting in extensive intergenic transcription. Similarly, …

CMVs efficiently target MHC I molecules to avoid recognition by cytotoxic T cells. However,
the lack of MHC I on the cell surface renders the infected cell susceptible to NK cell killing …

RNA–protein interactions are vital throughout the HIV-1 life cycle for the successful production
of infectious virus particles. One such essential RNA–protein interaction occurs between …

The genomes of both human cytomegalovirus (HCMV) and murine cytomegalovirus (MCMV)
were first sequenced over 20 years ago. Similar to HCMV, the MCMV genome had initially …