Odor stimulation evokes complex spatiotemporal activity in the olfactory bulb, suggesting
that both the identity of activated neurons and the timing of their activity convey information …

Ageing is driven by a loss of transcriptional and protein homeostasis 1 , 2 , 3 and is the key
risk factor for multiple chronic diseases. Interventions that attenuate or reverse systemic …

The mechanisms by which the diverse functional identities of neurons are generated are
poorly understood. C. elegans responds to thermal and chemical stimuli using 12 types of …

10.7554/eLife.31373.001 The neural control of social behaviors in rodents requires the
encoding of pheromonal cues by the vomeronasal system. Here we show that the typical …

10.7554/eLife.49158.001 Target of rapamycin complex 1 (TORC1) and AMP-activated
protein kinase (AMPK) antagonistically modulate metabolism and aging. However, how they …

Screens for zygotic lethal mutations that are associated with specific maternal effect lethal
phenotypes have only been conducted for the X chromosome. To identify loci on the …

Most C. elegans sensory neuron types consist of a single bilateral pair of neurons, and
respond to a unique set of sensory stimuli. Although genes required for the development and …

Individual cell types can elaborate morphologically diverse cilia. Cilia are assembled via
intraflagellar transport (IFT) of ciliary precursors; however, the mechanisms that generate ciliary …

We have generated a single-copy knock-in loci for defined gene expression (SKI LODGE)
system to insert any DNA by CRISPR/Cas9 at defined safe harbors in the Caenorhabditis …

Sensory signals regulate multiple developmental and behavioral circuits in C. elegans,
providing a genetically tractable system in which to investigate the mechanisms underlying the …