Many presynaptic transcripts have been observed in axons, yet their role in synapse
development remains unknown. Using visually and pharmacologically isolated presynaptic …

Electrical stimulation of nervous tissue is used clinically for the treatment of multiple neurological
disorders and experimentally for basic research. With the increase of optical probes to …

Neuronal growth cone filopodia contain guidance receptors and contribute to axon guidance;
however, the mechanism by which the guidance cue netrin increases filopodia density is …

The identification of mRNAs in distal projections of model organisms has led to the discovery
of multiple proteins that are locally synthesized for functional roles such as axon guidance, …

Injury of CNS nerve tracts remodels circuitry through dendritic spine loss and hyper-excitability,
thus influencing recovery. Due to the complexity of the CNS, a mechanistic …

Multi-compartment microfluidic devices have become valuable tools for experimental
neuroscientists, improving the organization of neurons and access to their distinct subcellular …

Use of microfluidic devices to compartmentalize cultured neurons has become a standard
method in neuroscience. This protocol shows how to use a pre-assembled multi-compartment …

The effort and cost of obtaining neurons for large-scale screens has limited drug discovery
in neuroscience. To overcome these obstacles, we fabricated arrays of releasable …

Microfabricated methods to compartmentalize neurons have become essential tools for
many neuroscientists. This protocol describes the use of a commercially available pre-…

Axon damage may cause axon regeneration, retrograde synapse loss, and hyper-excitability,
all of which affect recovery following acquired brain injury. While axon regeneration is …