Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells
C Duval, A Nègre-Salvayre, A Doglio… - … and cell biology, 2002 - cdnsciencepub.com
La protéine découplante 2 (UCP-2) fait partie de la famille des transporteurs anioniques
mitochondriaux. Elle est exprimée dans toutes les cellules, mais elle se trouve principalement …
mitochondriaux. Elle est exprimée dans toutes les cellules, mais elle se trouve principalement …
A role for uncoupling protein‐2 as a regulator of mitochondrial hydrogen peroxide generation
A Nègre‐Salvayre, C Hirtz, G Carrera… - The FASEB …, 1997 - Wiley Online Library
According to the state of mitochondrial respiration, the respiratory chain generates
superoxide anions converted into hydrogen peroxide. Two uncoupling proteins (UCP) able to …
superoxide anions converted into hydrogen peroxide. Two uncoupling proteins (UCP) able to …
[HTML][HTML] Angiogenesis in the atherosclerotic plaque
C Camaré, M Pucelle, A Nègre-Salvayre, R Salvayre - Redox biology, 2017 - Elsevier
Atherosclerosis is a multifocal alteration of the vascular wall of medium and large arteries
characterized by a local accumulation of cholesterol and non-resolving inflammation. …
characterized by a local accumulation of cholesterol and non-resolving inflammation. …
Induction of cancer cell apoptosis by α‐tocopheryl succinate: molecular pathways and structural requirements
…, B Olejnicka, A NÈGRE‐SALVAYRE… - The FASEB …, 2001 - Wiley Online Library
The vitamin E analog α‐tocopheryl succinate (α‐TOS) can induce apoptosis. We show that
the proapoptotic activity of α‐TOS in hematopoietic and cancer cell lines involves inhibition of …
the proapoptotic activity of α‐TOS in hematopoietic and cancer cell lines involves inhibition of …
Small, dense high-density lipoprotein-3 particles are enriched in negatively charged phospholipids: relevance to cellular cholesterol efflux, antioxidative …
…, W Le Goff, A Nègre-Salvayre, R Salvayre… - … , and vascular biology, 2013 - Am Heart Assoc
Objective— High-density lipoprotein (HDL) displays multiple atheroprotective activities and
is highly heterogeneous in structure, composition, and function; the molecular determinants …
is highly heterogeneous in structure, composition, and function; the molecular determinants …
HDL and ApoA prevent cell death of endothelial cells induced by oxidized LDL
…, M Troly, R Salvayre, A Nègre-Salvayre - … , and vascular biology, 1997 - Am Heart Assoc
We have previously demonstrated that toxic doses of mildly oxidized LDL evokes in cultured
cells a delayed and sustained rise of cytosolic [Ca 2+ ], eliciting in turn irreversible cell …
cells a delayed and sustained rise of cytosolic [Ca 2+ ], eliciting in turn irreversible cell …
Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors
A Negre‐Salvayre, C Coatrieux… - British journal of …, 2008 - Wiley Online Library
Reactive carbonyl compounds (RCCs) formed during lipid peroxidation and sugar glycoxidation,
namely Advanced lipid peroxidation end products (ALEs) and Advanced Glycation end …
namely Advanced lipid peroxidation end products (ALEs) and Advanced Glycation end …
Small, dense HDL 3 particles attenuate apoptosis in endothelial cells: pivotal role of apolipoprotein A‐I
…, C Vindis, A Nègre‐Salvayre… - Journal of cellular …, 2010 - Wiley Online Library
Plasma high‐density lipoproteins (HDLs) protect endothelial cells against apoptosis induced
by oxidized low‐density lipoprotein (oxLDL). The specific component(s) of HDLs implicated …
by oxidized low‐density lipoprotein (oxLDL). The specific component(s) of HDLs implicated …
Structural modifications of HDL and functional consequences
High density lipoproteins (HDL) are susceptible to structural modifications mediated by various
mechanisms including oxidation, glycation, homocysteinylation or enzymatic degradation…
mechanisms including oxidation, glycation, homocysteinylation or enzymatic degradation…
Oxidized low-density lipoproteins trigger endoplasmic reticulum stress in vascular cells: prevention by oxygen-regulated protein 150 expression
…, Y Sawa, R Salvayre, A Nègre-Salvayre - Circulation …, 2009 - Am Heart Assoc
Oxidized low-density lipoproteins (oxLDLs) trigger various biological responses potentially
involved in atherogenesis. Disturbing endoplasmic reticulum (ER) function results in ER …
involved in atherogenesis. Disturbing endoplasmic reticulum (ER) function results in ER …