Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function
of T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on …

Induction and maintenance of peripheral tolerance are important mechanisms to maintain
the balance of the immune system. In addition to the deletion of T cells and their failure to …

Development of the appropriate CD4 + T helper (T H ) subset during an immune response is
important for disease resolution. With the use of naive, ovalbumin-specific αβ T cell receptor …

IL-10 inhibits the ability of macrophage but not B cell APC to stimulate cytokine synthesis by
Th1 T cell clones. In this study we have examined the direct effects of IL-10 on both …

Interleukin-10 (IL-10), a cytokine with anti-inflammatory properties, has a central role in
infection by limiting the immune response to pathogens and thereby preventing damage to the …

Murine IL-10 (cytokine synthesis inhibitory factor) inhibits cytokine production by Th1 cell
clones when they are activated under conditions requiring the presence of APC. By …

Th1-and Th2-type cytokines (termed Th0) have been likely that the dose and route of
immunization of antigen described in human and mouse systems (Sher and Coffmay also be …

Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during
infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the …

Tuberculosis (TB), caused by infection with Mycobacterium tuberculosis, is a major cause of
morbidity and mortality worldwide. Efforts to control it are hampered by difficulties with …

Dendritic cells are APCs that are unique in their potency to stimulate proliferation of primary
Ag-specific responses in vitro and in vivo. In this study, we demonstrate that dendritic cells …