Necroptosis is considered to be complementary to the classical caspase-dependent programmed
cell death pathway, apoptosis. The pseudokinase Mixed Lineage Kinase Domain-Like …

Protein kinase-like domains that lack conserved residues known to catalyse phosphoryl
transfer, termed pseudokinases, have emerged as important signalling domains across all …

Anthracycline‐induced cardiotoxicity ( ACT ) is a severe adverse drug reaction for a subset of
children treated with anthracyclines as part of chemotherapy protocols. The identification of …

The pseudokinase, MLKL (mixed-lineage kinase domain-like), is the most terminal obligatory
component of the necroptosis cell death pathway known. Phosphorylation of the MLKL …

The pseudokinase MLKL (mixed lineage kinase domain-like), has recently emerged as a
critical component of the necroptosis cell death pathway. Although it is clear that …

MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have
isolated a mouse strain with a single missense mutation, Mlkl D139V , that alters the two-…

Background It has long been established that cardiotoxicity occurs as a result of exposure to
certain chemotherapeutics, particularly anthracyclines. Historically, clinicians equate …

We have isolated a mouse strain with a single missense mutation in the gene encoding MLKL,
the essential effector of necroptotic cell death. The resulting substitution lies within the two…

Introduction Anthracyclines are chemotherapeutic agents used in the treatment of over 70%
of childhood and adolescent malignancies and their use has significantly improved cancer …

A 16-year-old female survivor of childhood Acute Myeloid Leukaemia (AML) presented 12
weeks pregnant to her haematology oncology late effects appointment. Having failed to attend …