Sequence-specific nucleases like TALENs and the CRISPR/Cas9 system have greatly
expanded the genome editing possibilities in model organisms such as zebrafish. Both systems …

Telomeres and telomerase represent, at least in theory, an extremely attractive target for
cancer therapy. The objective of this review is to present the latest view on the mechanism(s) of …

The telomeric G-rich single-stranded DNA can adopt in vitro an intramolecular quadruplex
structure, which has been shown to directly inhibit telomerase activity. The reactivation of this …

Syntheses and telomeric G-quadruplex−DNA binding properties of novel bisquinolinium
compounds are reported. This series exhibits remarkable efficiency both in terms of stabilization …

Quadruplex ligands are often considered as telomerase inhibitors. Given the fact that some
of these molecules are present in the clinical setting, it is important to establish the validity of …

The melting of tetramolecular DNA or RNA quadruplexes is kinetically irreversible. However,
rather than being a hindrance, this kinetic inertia allows us to study association and …

Genome editing has now been reported in many systems using TALEN and CRISPR-Cas9
nucleases. Precise mutations can be introduced during homology-directed repair with donor …

The G-overhangs of telomeres are thought to adopt particular conformations, such as T-loops
or G-quadruplexes. It has been suggested that G-quadruplex structures could be stabilized …

We report here the details of G4-FID (G-quadruplex fluorescent intercalator displacement), a
simple method aiming at evaluating quadruplex-DNA binding affinity and quadruplex- over …

Parallel tetramolecular quadruplexes may be formed with short oligodeoxynucleotides
bearing a block of three or more guanines. We analyze the properties of sequence variants of …