Specific protein−protein interactions are crucial in the cell, both to ensure the formation and
stability of multiprotein complexes and to enable signal transduction in various pathways. …

Bacterial communities attached to surfaces under fluid flow represent a widespread lifestyle
of the microbial world. Through shear stress generation and molecular transport regulation, …

Functional protein-protein interactions are crucial in most cellular processes. They enable
multi-protein complexes to assemble and to remain stable, and they allow signal transduction …

A key question in evolution is how likely a mutant is to take over. This depends on natural
selection and on stochastic fluctuations. Population spatial structure can impact mutant fixation …

Determining which proteins interact together is crucial to a systems-level understanding of
the cell. Recently, algorithms based on Direct Coupling Analysis (DCA) pairwise maximum-…

The identification of cell borders (‘segmentation’) in microscopy images constitutes a bottleneck
for large-scale experiments. For the model organism Saccharomyces cerevisiae, current …

10.7554/eLife.03638.001 CTP Synthetase (CtpS) is a universally conserved and essential
metabolic enzyme. While many enzymes form small oligomers, CtpS forms large-scale …

Inferring protein-protein interactions from sequences is an important task in computational
biology. Recent methods based on Direct Coupling Analysis (DCA) or Mutual Information (MI) …

Most biological molecules contain acido-basic groups that modulate their structure and
interactions. A consequence is that pH gradients, local heterogeneities and dynamic variations …

The evolution of antimicrobial resistance can be strongly affected by variations of
antimicrobial concentration. Here, we study the impact of periodic alternations of absence and …